The Current Host Range of Hepatitis E Viruses

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2019 May 22

PMID 31108942

Citations 49

Authors

Scott P Kenney

Affiliations

Soon will be listed here.

Abstract

Hepatitis E virus (HEV) is an emerging zoonotic pathogen transmitting both human to human via the fecal oral route and from animals to humans through feces, direct contact, and consumption of contaminated meat products. Understanding the host range of the virus is critical for determining where potential threats to human health may be emerging from and where potential reservoirs for viral persistence in the environment may be hiding. Initially thought to be a human specific disease endemic to developing countries, the identification of swine as a primary host for genotypes 3 and 4 HEV in industrialized countries has begun a long journey of discovering novel strains of HEV and their animal hosts. As we continue identifying new strains of HEV in disparate animal species, it is becoming abundantly clear that HEV has a broad host range and many of these HEV strains can cross between differing animal species. These cross-species transmitting strains pose many unique challenges to human health as they are often unrecognized as sources of viral transmission.

Citing Articles

Palmitoylation-dependent association with Annexin II directs hepatitis E virus ORF3 sorting into vesicles and quasi-enveloped virions.

Liu X, Liu T, Shao Z, Xiong X, Qi S, Guan J Proc Natl Acad Sci U S A. 2025; 122(1):e2418751122.

PMID: 39793027 PMC: 11725905. DOI: 10.1073/pnas.2418751122.

Phosphorylation of Ser711 residue in the hypervariable region of zoonotic genotype 3 hepatitis E virus is important for virus replication.

Wang B, Subramaniam S, Tian D, Mahsoub H, Heffron C, Meng X mBio. 2024; 15(11):e0263524.

PMID: 39377575 PMC: 11559016. DOI: 10.1128/mbio.02635-24.

HEV-3 subtypes and strains detected in cases of HEV infection in central Italy from 2015 to 2023.

Garbuglia A, Koja G, Villano U, Minosse C, Equestre M, Pauciullo S Infection. 2024; .

PMID: 39254751 DOI: 10.1007/s15010-024-02348-0.

Serological survey on Hepatitis E virus in Namibian dogs, cats, horses, and donkeys.

Molini U, Franzo G, de Villiers L, van Zyl L, de Villiers M, Khaiseb S Front Vet Sci. 2024; 11:1422001.

PMID: 39091395 PMC: 11292797. DOI: 10.3389/fvets.2024.1422001.

Rat hepatitis E virus cross-species infection and transmission in pigs.

Yadav K, Boley P, Lee C, Khatiwada S, Jung K, Laocharoensuk T PNAS Nexus. 2024; 3(7):pgae259.

PMID: 39035038 PMC: 11259135. DOI: 10.1093/pnasnexus/pgae259.

References

Arankalle V, Paranjape S, Emerson S, Purcell R, Walimbe A . Phylogenetic analysis of hepatitis E virus isolates from India (1976-1993). J Gen Virol. 1999; 80 ( Pt 7):1691-1700. DOI: 10.1099/0022-1317-80-7-1691. View

Fine J, Elm J, Glass G, Higa H, Diwan A, Gibbs Jr C . Evidence for widespread infection of wild rats with hepatitis E virus in the United States. Am J Trop Med Hyg. 1999; 61(2):331-5. DOI: 10.4269/ajtmh.1999.61.331. View

Hsieh S, Meng X, Wu Y, Liu S, Tam A, Lin D . Identity of a novel swine hepatitis E virus in Taiwan forming a monophyletic group with Taiwan isolates of human hepatitis E virus. J Clin Microbiol. 1999; 37(12):3828-34. PMC: 85823. DOI: 10.1128/JCM.37.12.3828-3834.1999. View

Kibenge F, Whyte S, Hammell K, Rainnie D, Kibenge M, Martin C . A dual infection of infectious salmon anaemia (ISA) virus and a togavirus-like virus in ISA of Atlantic salmon Salmo salar in New Brunswick, Canada. Dis Aquat Organ. 2000; 42(1):11-5. DOI: 10.3354/dao042011. View

Meng X . Novel strains of hepatitis E virus identified from humans and other animal species: is hepatitis E a zoonosis?. J Hepatol. 2000; 33(5):842-5. DOI: 10.1016/s0168-8278(00)80319-0. View

Arankalle V, Joshi M, Kulkarni A, Gandhe S, Chobe L, Rautmare S . Prevalence of anti-hepatitis E virus antibodies in different Indian animal species. J Viral Hepat. 2001; 8(3):223-7. DOI: 10.1046/j.1365-2893.2001.00290.x. View

Haqshenas G, Shivaprasad H, Woolcock P, Read D, Meng X . Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis-splenomegaly syndrome in the United States. J Gen Virol. 2001; 82(Pt 10):2449-2462. DOI: 10.1099/0022-1317-82-10-2449. View

Aggarwal R, Kamili S, Spelbring J, Krawczynski K . Experimental studies on subclinical hepatitis E virus infection in cynomolgus macaques. J Infect Dis. 2001; 184(11):1380-5. DOI: 10.1086/324376. View

Huang C, Nguyen D, Fernandez J, Yun K, FRY K, Bradley D . Molecular cloning and sequencing of the Mexico isolate of hepatitis E virus (HEV). Virology. 1992; 191(2):550-8. DOI: 10.1016/0042-6822(92)90230-m. View

10.

Stremlau M, Owens C, Perron M, Kiessling M, Autissier P, Sodroski J . The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature. 2004; 427(6977):848-53. DOI: 10.1038/nature02343. View

11.

Sun Z, Larsen C, Huang F, Billam P, Pierson F, Toth T . Generation and infectivity titration of an infectious stock of avian hepatitis E virus (HEV) in chickens and cross-species infection of turkeys with avian HEV. J Clin Microbiol. 2004; 42(6):2658-62. PMC: 427805. DOI: 10.1128/JCM.42.6.2658-2662.2004. View

12.

Sonoda H, Abe M, Sugimoto T, Sato Y, Bando M, Fukui E . Prevalence of hepatitis E virus (HEV) Infection in wild boars and deer and genetic identification of a genotype 3 HEV from a boar in Japan. J Clin Microbiol. 2004; 42(11):5371-4. PMC: 525261. DOI: 10.1128/JCM.42.11.5371-5374.2004. View

13.

Ticehurst J, Rhodes Jr L, Krawczynski K, Asher L, Engler W, Mensing T . Infection of owl monkeys (Aotus trivirgatus) and cynomolgus monkeys (Macaca fascicularis) with hepatitis E virus from Mexico. J Infect Dis. 1992; 165(5):835-45. DOI: 10.1093/infdis/165.5.835. View

14.

Huang F, Pierson F, Toth T, Meng X . Construction and characterization of infectious cDNA clones of a chicken strain of hepatitis E virus (HEV), avian HEV. J Gen Virol. 2005; 86(Pt 9):2585-2593. DOI: 10.1099/vir.0.81070-0. View

15.

Guo H, Zhou E, Sun Z, Meng X, Halbur P . Identification of B-cell epitopes in the capsid protein of avian hepatitis E virus (avian HEV) that are common to human and swine HEVs or unique to avian HEV. J Gen Virol. 2005; 87(Pt 1):217-223. DOI: 10.1099/vir.0.81393-0. View

16.

Nakamura M, Takahashi K, Taira K, Taira M, Ohno A, Sakugawa H . Hepatitis E virus infection in wild mongooses of Okinawa, Japan: Demonstration of anti-HEV antibodies and a full-genome nucleotide sequence. Hepatol Res. 2006; 34(3):137-40. DOI: 10.1016/j.hepres.2005.10.010. View

17.

Li T, Saito M, Ogura G, Ishibashi O, Miyamura T, Takeda N . Serologic evidence for hepatitis E virus infection in mongoose. Am J Trop Med Hyg. 2006; 74(5):932-6. View

18.

Saad M, Hussein H, Bashandy M, Kamel H, Earhart K, Fryauff D . Hepatitis E virus infection in work horses in Egypt. Infect Genet Evol. 2006; 7(3):368-73. DOI: 10.1016/j.meegid.2006.07.007. View

19.

Mochizuki M, Ouchi A, Kawakami K, Ishida T, Li T, Takeda N . Epidemiological study of hepatitis E virus infection of dogs and cats in Japan. Vet Rec. 2006; 159(25):853-4. View

20.

Easterbrook J, Kaplan J, Vanasco N, Reeves W, Purcell R, Kosoy M . A survey of zoonotic pathogens carried by Norway rats in Baltimore, Maryland, USA. Epidemiol Infect. 2007; 135(7):1192-9. PMC: 2870671. DOI: 10.1017/S0950268806007746. View