Role of Transforming Growth Factor-β in Skeletal Muscle Fibrosis: A Review

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 May 22

PMID 31108916

Citations 61

Authors

Ahmed Ismaeel

Jeong-Su Kim

Jeffrey S Kirk

Robert S Smith

William T Bohannon

Panagiotis Koutakis

Affiliations

Soon will be listed here.

Abstract

Transforming growth factor-beta (TGF-β) isoforms are cytokines involved in a variety of cellular processes, including myofiber repair and regulation of connective tissue formation. Activation of the TGF-β pathway contributes to pathologic fibrosis in most organs. Here, we have focused on examining the evidence demonstrating the involvement of TGF-β in the fibrosis of skeletal muscle particularly. The TGF-β pathway plays a role in different skeletal muscle myopathies, and TGF-β signaling is highly induced in these diseases. In this review, we discuss different molecular mechanisms of TGF-β-mediated skeletal muscle fibrosis and highlight different TGF-β-targeted treatments that target these relevant pathways.

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