The Effects of Repeated Doses of Ethanol on Exploration and Its Habituation

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1987 Jan 1

PMID 3110832

Citations 11

Authors

R G Lister

Affiliations

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Abstract

The effects of ethanol (0.8-2.4 g/kg) on exploratory behavior and its habituation were investigated by testing DBA/2 mice in a holeboard apparatus. Mice familiar with the holeboard had lower levels of exploration than animals with no previous experience in the apparatus. If the animals received ethanol during their first exposure to the holeboard they did not show the same degree of habituation. Ethanol (0.8 g/kg) increased the exploration of animals naive to the holeboard, but failed significantly to increase the exploration of animals familiar with the apparatus. An increase in locomotor activity was observed following treatment with ethanol (2.4 g/kg). This was potentiated if animals received a single treatment with ethanol 3 days earlier, but only if they were tested in the apparatus following the initial treatment. These results have important implications for the design of experiments investigating tolerance and sensitization to ethanol's effects on locomotor activity and exploration.

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References

Marriott A, Spencer P . Effects of centrally acting drugs on exploratory behaviour in rats. Br J Pharmacol Chemother. 1965; 25(2):432-41. PMC: 1510738. DOI: 10.1111/j.1476-5381.1965.tb02062.x. View

Post R, Lockfeld A, Squillace K, Contel N . Drug-environment interaction: context dependency of cocaine-induced behavioral sensitization. Life Sci. 1981; 28(7):755-60. DOI: 10.1016/0024-3205(81)90157-0. View

Hunt G, Overstreet D . Evidence for parallel development of tolerance to the hyperactivating and discoordinating effects of ethanol. Psychopharmacology (Berl). 1977; 55(1):75-81. DOI: 10.1007/BF00432820. View

Lister R, File S . The effect of chlordiazepoxide on the habituation of exploration: interactions with the benzodiazepine antagonist RO 15-1788. Pharmacol Biochem Behav. 1987; 26(3):631-4. DOI: 10.1016/0091-3057(87)90177-8. View

Lister R . The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berl). 1987; 92(2):180-5. DOI: 10.1007/BF00177912. View

MCQUARRIE D, FINGL E . Effects of single doses and chronic administration of ethanol on experimental seizures in mice. J Pharmacol Exp Ther. 1958; 124(3):264-71. View

File S . What can be learned from the effects of benzodiazepines on exploratory behavior?. Neurosci Biobehav Rev. 1985; 9(1):45-54. DOI: 10.1016/0149-7634(85)90031-4. View

Robbins T, Iversen S . A dissociation of the effects of d-amphetamine on locomotor activity and exploration in rats. Psychopharmacologia. 1973; 28(2):155-64. DOI: 10.1007/BF00421400. View

File S . Effects of chlorpromazine on exploration and habituation in the rat. Br J Pharmacol. 1973; 49(2):303-10. PMC: 1776385. DOI: 10.1111/j.1476-5381.1973.tb08376.x. View

10.

Crabbe Jr J, Johnson N, Gray D, Kosobud A, Young E . Biphasic effects of ethanol on open-field activity: sensitivity and tolerance in C57BL/6N and DBA/2N mice. J Comp Physiol Psychol. 1982; 96(3):440-51. DOI: 10.1037/h0077898. View

11.

File S . Effects of parachlorophenylalanine and amphetamine on habituation of exploration. Pharmacol Biochem Behav. 1977; 6(2):151-6. DOI: 10.1016/0091-3057(77)90065-x. View

12.

Nolan N, PARKES M . The effects of benzodiazepines on the behaviour of mice on a hole-board. Psychopharmacologia. 1973; 29(3):277-86. DOI: 10.1007/BF00414043. View

13.

Williams J, Hamilton L, Carlton P . Pharmacological and anatomical dissociation of two types of habituation. J Comp Physiol Psychol. 1974; 87(4):724-32. DOI: 10.1037/h0036963. View

14.

Platel A, Porsolt R . Habituation of exploratory activity in mice: a screening test for memory enhancing drugs. Psychopharmacology (Berl). 1982; 78(4):346-52. DOI: 10.1007/BF00433739. View

15.

Masur J, Oliveira de Souza M, Zwicker A . The excitatory effect of ethanol: absence in rats, no tolerance and increased sensitivity in mice. Pharmacol Biochem Behav. 1986; 24(5):1225-8. DOI: 10.1016/0091-3057(86)90175-9. View

16.

Lister R . The effects of ethanol on exploration in DBA/2 and C57Bl/6 mice. Alcohol. 1987; 4(1):17-9. DOI: 10.1016/0741-8329(87)90054-1. View

17.

Rushton R, Steinberg H, Tomkiewicz M . Equivalence and persistence of the effects of psychoactive drugs and past experience. Nature. 1968; 220(5170):885-9. DOI: 10.1038/220885a0. View

18.

Tabakoff B, Kiianmaa K . Does tolerance develop to the activating, as well as the depressant, effects of ethanol?. Pharmacol Biochem Behav. 1982; 17(5):1073-6. DOI: 10.1016/0091-3057(82)90496-8. View

19.

Rushton R, Steinberg H, TINSON C . Effects of a single experience on subsequent reactions to drugs. Br J Pharmacol Chemother. 1963; 20:99-105. PMC: 1703735. DOI: 10.1111/j.1476-5381.1963.tb01301.x. View

20.

File S, Wardill A . Validity of head-dipping as a measure of exploration in a modified hole-board. Psychopharmacologia. 1975; 44(1):53-9. DOI: 10.1007/BF00421184. View