The Effect of Depressive-like Behavior and Antidepressant Therapy on Social Behavior and Hierarchy in Rats

Overview

Journal Behav Brain Res

Specialties Neurology
Psychology
Social Sciences

Date 2019 May 21

PMID 31108115

Citations 4

Authors

Matthew Boyko

Ruslan Kutz

Julia Grinshpun

Vladislav Zvenigorodsky

Benjamin F Gruenbaum

Shaun E Gruenbaum

Amit Frenkel

Evgeni Brotfain

Israel Melamed

Dmitry Frank

Vladimir Zeldetz

Alexander Zlotnik

Affiliations

Soon will be listed here.

Abstract

Background: Depression is common and results in a significant morbidity and economic burden. Depression is associated with pervasive impairments in social functioning, and antidepressant treatments are highly variable in improving these impairments. The objectives of this study were to test the effects of depression on social organization and behavior in a rodent model of depression, and to study the effectiveness of antidepressant medication in improving both symptoms of depression and the social function of depressed animals.

Methods: One hundred-twenty male Sprague-Dawley rats were randomly and equally divided between the control group and depression group. After induction of depression by 5 weeks of chronic unpredictable stress, rats received either antidepressant treatment or placebo. In parallel with the initiation of drug therapy, 20 social groups of six rats were subjected to the complex diving-for-food situation to evaluate their social functioning. Four behavioral tests evaluated symptoms of depression and anxiety at 3 different time points.

Results: We found that 1) depressed rats were significantly more active and aggressive in all parameters of social organization test compared with the control and antidepressant treatment groups, 2) depressed rats that received antidepressant treatment exhibited social behaviors like the control group, and 3) depression in the experimental groups was not accompanied by symptoms of anxiety.

Conclusions: These results suggest that depression can significantly alter the social behavior and hierarchy in the social group in rats. Investigations of complex social group dynamics offer novel opportunities for translational studies of mood and psychiatric disorders.

Citing Articles

Comparative Evaluation of Antidepressant and Anxiolytic Effects of Escitalopram, Crocin, and their Combination in Rats.

Joodaki M, Radahmadi M, Alaei H Adv Biomed Res. 2024; 13:99.

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Blood glutamate scavenging as a novel glutamate-based therapeutic approach for post-traumatic brain injury anxiety and social impairment.

Frank D, Gruenbaum B, Shelef I, Zvenigorodsky V, Severynovska O, Fleidervish I Transl Psychiatry. 2023; 13(1):41.

PMID: 36739271 PMC: 9899234. DOI: 10.1038/s41398-023-02329-1.

Traumatic brain injury-induced submissive behavior in rats: link to depression and anxiety.

Boyko M, Gruenbaum B, Shelef I, Zvenigorodsky V, Severynovska O, Binyamin Y Transl Psychiatry. 2022; 12(1):239.

PMID: 35672289 PMC: 9174479. DOI: 10.1038/s41398-022-01991-1.

Blood Glutamate Scavenging With Pyruvate as a Novel Preventative and Therapeutic Approach for Depressive-Like Behavior Following Traumatic Brain Injury in a Rat Model.

Frank D, Gruenbaum B, Shelef I, Zvenigorodsky V, Severynovska O, Gal R Front Neurosci. 2022; 16:832478.

PMID: 35237125 PMC: 8883046. DOI: 10.3389/fnins.2022.832478.

References

Elgarf A, Aboul-Fotouh S, Abd-Alkhalek H, El Tabbal M, Hassan A, Kassim S . Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline. Pharmacol Biochem Behav. 2014; 126:152-62. DOI: 10.1016/j.pbb.2014.09.014. View

Paykel E, Weissman M, Prusoff B, TONKS C . Dimensions of social adjustment in depressed women. J Nerv Ment Dis. 1971; 152(3):158-72. DOI: 10.1097/00005053-197103000-00002. View

Fokos S, Panagis G . Effects of delta9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress. J Psychopharmacol. 2009; 24(5):767-77. DOI: 10.1177/0269881109104904. View

Malatynska E, Pinhasov A, Crooke J, Smith-Swintosky V, Brenneman D . Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: technical considerations. J Neurosci Methods. 2007; 165(2):175-82. DOI: 10.1016/j.jneumeth.2007.05.035. View

Kennedy N, Foy K, Sherazi R, McDonough M, McKeon P . Long-term social functioning after depression treated by psychiatrists: a review. Bipolar Disord. 2007; 9(1-2):25-37. DOI: 10.1111/j.1399-5618.2007.00326.x. View

Grasmuck V, Desor D . Behavioural differentiation of rats confronted to a complex diving-for-food situation. Behav Processes. 2002; 58(1-2):67-77. DOI: 10.1016/s0376-6357(01)00209-1. View

Ismail B, Aboul-Fotouh S, Mansour A, Shehata H, Salman M, Ibrahim E . Behavioural, metabolic, and endothelial effects of the TNF-α suppressor thalidomide on rats subjected to chronic mild stress and fed an atherogenic diet. Can J Physiol Pharmacol. 2014; 92(5):375-85. DOI: 10.1139/cjpp-2013-0446. View

Vyas A, Chattarji S . Modulation of different states of anxiety-like behavior by chronic stress. Behav Neurosci. 2004; 118(6):1450-4. DOI: 10.1037/0735-7044.118.6.1450. View

Zanier-Gomes P, de Abreu Silva T, Zanetti G, Benati E, Pinheiro N, Murta B . Depressive behavior induced by social isolation of predisposed female rats. Physiol Behav. 2015; 151:292-7. DOI: 10.1016/j.physbeh.2015.07.026. View

10.

Daruna J, Kent E . Comparison of regional serotonin levels and turnover in the brain of naturally high and low aggressive rats. Brain Res. 1976; 101(3):489-501. DOI: 10.1016/0006-8993(76)90473-x. View

11.

Sapolsky R . The influence of social hierarchy on primate health. Science. 2005; 308(5722):648-52. DOI: 10.1126/science.1106477. View

12.

Hirschfeld R, Montgomery S, Keller M, Kasper S, Schatzberg A, Moller H . Social functioning in depression: a review. J Clin Psychiatry. 2000; 61(4):268-75. DOI: 10.4088/jcp.v61n0405. View

13.

Boyko M, Kutz R, Gruenbaum B, Cohen H, Kozlovsky N, Gruenbaum S . The influence of aging on poststroke depression using a rat model via middle cerebral artery occlusion. Cogn Affect Behav Neurosci. 2013; 13(4):847-59. DOI: 10.3758/s13415-013-0177-3. View

14.

Sanderson W, Wetzler S, Beck A, Betz F . Prevalence of personality disorders in patients with major depression and dysthymia. Psychiatry Res. 1992; 42(1):93-9. DOI: 10.1016/0165-1781(92)90042-2. View

15.

Willner P . Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl). 1998; 134(4):319-29. DOI: 10.1007/s002130050456. View

16.

Schweizer M, Henniger M, Sillaber I . Chronic mild stress (CMS) in mice: of anhedonia, 'anomalous anxiolysis' and activity. PLoS One. 2009; 4(1):e4326. PMC: 2627902. DOI: 10.1371/journal.pone.0004326. View

17.

Guelfi J . [Depression and personality disorders]. Rev Prat. 2008; 58(4):373-6. View

18.

Helder R, Desor D, Toniolo A . Potential stock differences in the social behavior of rats in a situation of restricted access to food. Behav Genet. 1995; 25(5):483-7. DOI: 10.1007/BF02253377. View

19.

Deviterne D, Peignot P, Krafft B . Behavioral profiles of adult rats in a difficult food supply social situation, related to certain early behavioral features. Dev Psychobiol. 1994; 27(4):215-25. DOI: 10.1002/dev.420270404. View

20.

Thullier F, Desor D, Mos J, Krafft B . Effect of group size on social organization in rats with restricted access to food. Physiol Behav. 1992; 52(1):17-20. DOI: 10.1016/0031-9384(92)90427-4. View