Novel Orthobunyavirus Causing Severe Kidney Disease in Broiler Chickens, Malaysia, 2014-2017

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2019 May 21

PMID 31107212

Citations 4

Authors

Vilmos Palya

Edit Walkone Kovacs

Szilvia Marton

Timea Tatar-Kis

Balazs Felfoldi

Barbara Forro

Marianna Doman

Krisztian Banyai

Affiliations

Soon will be listed here.

Abstract

During 2014-2017, we isolated a novel orthobunyavirus from broiler chickens with severe kidney lesions in the state of Kedah, Malaysia; we named the virus Kedah fatal kidney syndrome virus (KFKSV). Affected chickens became listless and diarrheic before dying suddenly. Necropsies detected pale and swollen kidneys with signs of gout, enlarged and fragile livers, and pale hearts. Experimental infection of broiler chickens with KFKSV reproduced the disease and pathologic conditions observed in the field, fulfilling the Koch's postulates. Gene sequencing indicated high nucleotide identities between KFKSV isolates (99%) and moderate nucleotide identities with the orthobunyavirus Umbre virus in the large (78%), medium (77%), and small (86%) genomic segments. KFKSV may be pathogenic for other host species, including humans.

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