» Articles » PMID: 31105886

Roles of GLUT-1 and HK-II Expression in the Biological Behavior of Head and Neck Cancer

Overview
Journal Oncotarget
Specialty Oncology
Date 2019 May 21
PMID 31105886
Citations 25
Authors
Affiliations
Soon will be listed here.
Abstract

The Warburg effect plays an important role in the proliferation and invasion of malignant tumors. Glucose transporter 1 and hexokinase II are two key energy transporters involved in mediating the Warburg effect. This review will analyze the mechanisms of these two markers in their effects on the biological behavior of head and neck cancer.

Citing Articles

Proliferation and migration inhibition of adenoid cystic carcinoma cells through autophagy suppression via GLUT1 knockdown.

Liu K, Zhu J, Bao Y, Fang J, Zhou S, Fan J Heliyon. 2025; 11(4):e42894.

PMID: 40070961 PMC: 11894374. DOI: 10.1016/j.heliyon.2025.e42894.


Momordicine-I suppresses head and neck cancer growth by modulating key metabolic pathways.

Bandyopadhyay D, Tran E, Patel R, Luetzen M, Cho K, Shriver L Cell Commun Signal. 2024; 22(1):597.

PMID: 39696286 PMC: 11657802. DOI: 10.1186/s12964-024-01951-w.


A Significant Increasing Risk Association between Cigarette Smoking and and Genes Polymorphisms.

Almushawwah S, Almutairi M, Alamri A, Semlali A Genes (Basel). 2023; 14(7).

PMID: 37510255 PMC: 10379612. DOI: 10.3390/genes14071349.


RNA-Based Liquid Biopsy in Head and Neck Cancer.

Kabzinski J, Kucharska-Lusina A, Majsterek I Cells. 2023; 12(14).

PMID: 37508579 PMC: 10377854. DOI: 10.3390/cells12141916.


Moonlight functions of glycolytic enzymes in cancer.

Shegay P, Shatova O, Zabolotneva A, Shestopalov A, Kaprin A Front Mol Biosci. 2023; 10:1076138.

PMID: 37449059 PMC: 10337784. DOI: 10.3389/fmolb.2023.1076138.


References
1.
Younes M, Juarez D, Lechago L, Lerner S . Glut 1 expression in transitional cell carcinoma of the urinary bladder is associated with poor patient survival. Anticancer Res. 2001; 21(1B):575-8. View

2.
Nakata B, Nishimura S, Ishikawa T, Ohira M, Nishino H, Kawabe J . Prognostic predictive value of 18F-fluorodeoxyglucose positron emission tomography for patients with pancreatic cancer. Int J Oncol. 2001; 19(1):53-8. DOI: 10.3892/ijo.19.1.53. View

3.
Williams K, Telfer B, Airley R, Peters H, Sheridan M, van der Kogel A . A protective role for HIF-1 in response to redox manipulation and glucose deprivation: implications for tumorigenesis. Oncogene. 2002; 21(2):282-90. DOI: 10.1038/sj.onc.1205047. View

4.
Higashi T, Saga T, Nakamoto Y, Ishimori T, Mamede M, Wada M . Relationship between retention index in dual-phase (18)F-FDG PET, and hexokinase-II and glucose transporter-1 expression in pancreatic cancer. J Nucl Med. 2002; 43(2):173-80. View

5.
Zimmerman R, Fogt F, Burke M, Murakata L . Assessment of Glut-1 expression in cholangiocarcinoma, benign biliary lesions and hepatocellular carcinoma. Oncol Rep. 2002; 9(4):689-92. View