Stress and Nicotine During Adolescence Disrupts Adult Hippocampal-dependent Learning and Alters Stress Reactivity

Overview

Journal Addict Biol

Specialty Psychiatry

Date 2019 May 18

PMID 31099135

Citations 8

Authors

Erica D Holliday

Sheree F Logue

Chicora Oliver

Debra A Bangasser

Thomas J Gould

Affiliations

Soon will be listed here.

Abstract

Adolescence represents increased susceptibility to stress that increases risk for nicotine dependence. The present study examined the interactive effects of brief exposure to stress (shipping/transportation or experimentally induced) and chronic nicotine during adolescence on cognitive function and stress reactivity in adulthood. Adolescent (P31), but not young adult (P47), C57BL/6J mice had higher levels of corticosterone after shipping vs mice bred onsite. Shipped preadolescent (P23) and adolescent (P38) mice, but not those bred onsite, exposed to nicotine showed deficits in contextual fear learning when tested in adulthood. Adult learning deficits were replicated in adolescent mice bred onsite, exposed to experimentally induced stress, and administered chronic nicotine. Stress and nicotine during adolescence resulted in higher expression of hippocampal glucocorticoid receptors and corticotropin-releasing factor receptors and blunted restraint induced CORT release in adulthood. Importantly, studies examining adolescent behavior in mice should consider stress influences outcomes.

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