Current Treatments for Obesity

Overview

Journal Clin Med (Lond)

Specialty General Medicine

Date 2019 May 17

PMID 31092512

Citations 72

Authors

Aruchuna Ruban

Kostadin Stoenchev

Hutan Ashrafian

Julian Teare

Affiliations

Soon will be listed here.

Abstract

Obesity is a major health and economic crisis facing the modern world. It is associated with excess mortality and morbidity and is directly linked to common conditions such as type 2 diabetes mellitus, coronary heart disease and sleep apnoea. The management of obesity and its associated complications has evolved in recent years, with a shift towards more definitive strategies such as bariatric surgery. This review encompasses the dietary, pharmacological and surgical strategies currently available for the management of obesity.

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References

Higa K, Boone K, Ho T, Davies O . Laparoscopic Roux-en-Y gastric bypass for morbid obesity: technique and preliminary results of our first 400 patients. Arch Surg. 2000; 135(9):1029-33; discussion 1033-4. DOI: 10.1001/archsurg.135.9.1029. View

Fielding G, Allen J . A step-by-step guide to placement of the LAP-BAND adjustable gastric banding system. Am J Surg. 2003; 184(6B):26S-30S. DOI: 10.1016/s0002-9610(02)01176-5. View

Conceicao E, Vaz A, Bastos A, Ramos A, Machado P . The development of eating disorders after bariatric surgery. Eat Disord. 2013; 21(3):275-82. DOI: 10.1080/10640266.2013.779193. View

Meloni A, DeYoung M, Lowe C, Parkes D . GLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependence. Diabetes Obes Metab. 2012; 15(1):15-27. PMC: 3556522. DOI: 10.1111/j.1463-1326.2012.01663.x. View

Mingrone G, Panunzi S, De Gaetano A, Guidone C, Iaconelli A, Leccesi L . Bariatric surgery versus conventional medical therapy for type 2 diabetes. N Engl J Med. 2012; 366(17):1577-85. DOI: 10.1056/NEJMoa1200111. View

Ballesta C, Berindoague R, Cabrera M, Palau M, Gonzales M . Management of anastomotic leaks after laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2008; 18(6):623-30. DOI: 10.1007/s11695-007-9297-6. View

Koehestanie P, de Jonge C, Berends F, Janssen I, Bouvy N, Greve J . The effect of the endoscopic duodenal-jejunal bypass liner on obesity and type 2 diabetes mellitus, a multicenter randomized controlled trial. Ann Surg. 2014; 260(6):984-92. DOI: 10.1097/SLA.0000000000000794. View

Backman O, Stockeld D, Rasmussen F, Naslund E, Marsk R . Alcohol and substance abuse, depression and suicide attempts after Roux-en-Y gastric bypass surgery. Br J Surg. 2016; 103(10):1336-42. DOI: 10.1002/bjs.10258. View

Greenway F, Fujioka K, Plodkowski R, Mudaliar S, Guttadauria M, Erickson J . Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2010; 376(9741):595-605. DOI: 10.1016/S0140-6736(10)60888-4. View

10.

Colquitt J, Pickett K, Loveman E, Frampton G . Surgery for weight loss in adults. Cochrane Database Syst Rev. 2014; (8):CD003641. PMC: 9028049. DOI: 10.1002/14651858.CD003641.pub4. View

11.

Cottam D, Qureshi F, Mattar S, Sharma S, Holover S, Bonanomi G . Laparoscopic sleeve gastrectomy as an initial weight-loss procedure for high-risk patients with morbid obesity. Surg Endosc. 2006; 20(6):859-63. DOI: 10.1007/s00464-005-0134-5. View

12.

Higa K, Ho T, Boone K . Internal hernias after laparoscopic Roux-en-Y gastric bypass: incidence, treatment and prevention. Obes Surg. 2003; 13(3):350-4. DOI: 10.1381/096089203765887642. View

13.

Sethi M, Chau E, Youn A, Jiang Y, Fielding G, Ren-Fielding C . Long-term outcomes after biliopancreatic diversion with and without duodenal switch: 2-, 5-, and 10-year data. Surg Obes Relat Dis. 2016; 12(9):1697-1705. DOI: 10.1016/j.soard.2016.03.006. View

14.

Shyangdan D, Royle P, Clar C, Sharma P, Waugh N, Snaith A . Glucagon-like peptide analogues for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2011; (10):CD006423. PMC: 6486297. DOI: 10.1002/14651858.CD006423.pub2. View

15.

Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M . A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015; 373(1):11-22. DOI: 10.1056/NEJMoa1411892. View

16.

Hayes J, Bhaskaran K, Batterham R, Smeeth L, Douglas I . The effect of sibutramine prescribing in routine clinical practice on cardiovascular outcomes: a cohort study in the United Kingdom. Int J Obes (Lond). 2015; 39(9):1359-64. PMC: 4551415. DOI: 10.1038/ijo.2015.86. View

17.

Blundell J, Macdiarmid J . Fat as a risk factor for overconsumption: satiation, satiety, and patterns of eating. J Am Diet Assoc. 1997; 97(7 Suppl):S63-9. DOI: 10.1016/s0002-8223(97)00733-5. View

18.

Huxley R, Mendis S, Zheleznyakov E, Reddy S, Chan J . Body mass index, waist circumference and waist:hip ratio as predictors of cardiovascular risk--a review of the literature. Eur J Clin Nutr. 2009; 64(1):16-22. DOI: 10.1038/ejcn.2009.68. View

19.

Lean M, Leslie W, Barnes A, Brosnahan N, Thom G, McCombie L . Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet. 2017; 391(10120):541-551. DOI: 10.1016/S0140-6736(17)33102-1. View

20.

le Roux C, Welbourn R, Werling M, Osborne A, Kokkinos A, Laurenius A . Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann Surg. 2007; 246(5):780-5. DOI: 10.1097/SLA.0b013e3180caa3e3. View