Antioxidative Property and Molecular Mechanisms Underlying Geniposide-Mediated Therapeutic Effects in Diabetes Mellitus and Cardiovascular Disease

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2019 May 16

PMID 31089416

Citations 19

Authors

Ning Li

Ling Li

Haiming Wu

Heng Zhou

Affiliations

Soon will be listed here.

Abstract

Geniposide, an iridoid glucoside, is a major component in the fruit of Ellis (Gardenia fruits). Geniposide has been experimentally proved to possess multiple pharmacological actions involving antioxidative stress, anti-inflammatory, antiapoptosis, antiangiogenesis, antiendoplasmic reticulum stress (ERS), etc. studies have further identified the value of geniposide in a spectrum of preclinical models of diabetes mellitus (DM) and cardiovascular disorders. The antioxidative property of geniposide should be attributed to the result of either the inhibition of numerous pathological processes or the activation of various proteins associated with cell survival or a combination of both. In this review, we will summarize the available knowledge on the antioxidative property and protective effects of geniposide in DM and cardiovascular disease in the literature and discuss antioxidant mechanisms as well as its potential applications in clinic.

Citing Articles

Geniposide alleviates post-myocardial infarction-induced pyroptosis by modulating the thioredoxin-interacting protein/NLRP3 signaling pathway.

Jiang Y, Su Y, Li C, Jiang W, Wei Y, Chang G Cytojournal. 2025; 21:80.

PMID: 39916997 PMC: 11801652. DOI: 10.25259/Cytojournal_139_2024.

Gardenia jasminoides fruit extract alleviates non-steroidal anti-inflammatory drug-induced gastropathy in rats.

Worapongpaiboon R, Kaikaew K, Werawatganone P, Somanawat K, Lerttanatum N, Klaikeaw N BMC Complement Med Ther. 2024; 24(1):401.

PMID: 39558310 PMC: 11571583. DOI: 10.1186/s12906-024-04702-z.

Exploring the role of NLRP3 inflammasome in diabetic nephropathy and the advancements in herbal therapeutics.

Jin J, Zhang M Front Endocrinol (Lausanne). 2024; 15:1397301.

PMID: 39104818 PMC: 11299242. DOI: 10.3389/fendo.2024.1397301.

Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis regulation of gut microbiota and bile acid signaling in a mouse model .

Li H, Xi Y, Xin X, Feng Q, Hu Y Front Pharmacol. 2023; 14:1148737.

PMID: 37077819 PMC: 10106595. DOI: 10.3389/fphar.2023.1148737.

Natural Monoterpenes as Potential Therapeutic Agents against Atherosclerosis.

Yang J, Zhong C, Yu J Int J Mol Sci. 2023; 24(3).

PMID: 36768748 PMC: 9917110. DOI: 10.3390/ijms24032429.

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