Association of Current Infection and Metabolic Factors with Gastric Cancer in 35,519 Subjects: A Cross-sectional Study

Overview

Journal United European Gastroenterol J

Publisher Wiley

Specialty Gastroenterology

Date 2019 May 14

PMID 31080613

Citations 17

Authors

Su Youn Nam

Bum Joon Park

Ji Hyung Nam

Kum Hei Ryu

Myeong-Cherl Kook

Jeongseon Kim

Won Kee Lee

Affiliations

Soon will be listed here.

Abstract

Background: The effect of current infection of on gastric cancer has rarely been studied in a large population. We investigated the association of current infection and metabolic factors with gastric cancer in a large population.

Methods: Persons who made their first visit to the National Cancer Center for a health examination, including endoscopy and testing using gastric tissue between 2003 and 2013, were included. The association of with gastric cancer was estimated using odds ratios (ORs) and 95% confidence intervals (CIs).

Results: Among 35,519 people, 113 gastric cancer and 158 gastric dysplasia cases were detected. In the adjusted analysis, gastric cancer was associated with current infection (OR, 2.39; 95% CI, 1.53-3.74), age (OR, 1.06; 95% CI 1.04-1.08), first-degree relatives with gastric cancer (OR, 2.08; 95% CI, 1.30-3.32) and hyperglycaemia (OR, 1.66; 95% CI, 1.04-2.65), whereas it was inversely associated with high-density lipoprotein (HDL) (OR, 0.49; 95% CI, 0.22-0.94). In the subanalysis, gastric cancer was associated with first-degree relatives with gastric cancer (OR, 3.23; 95% CI, 1.39-7.50) in the absence of , whereas it was associated with hyperglycaemia (OR, 1.98; 95% CI, 1.16-3.39) in the presence of

Conclusions: Gastric cancer was associated with current infection, hyperglycaemia, and low HDL levels in a large population.

Citing Articles

Immune Cell Crisis and Excess Histopathological Features During the Development and Progression of Infection in the Gastric Mucosa.

Wang S, Wang Y, Li P, Kong L, Deng W, Jiang B Int J Gen Med. 2025; 18:1345-1357.

PMID: 40065979 PMC: 11892368. DOI: 10.2147/IJGM.S474925.

Immune cell changes in infection-induced glandular epithelial cell damage of the gastric mucosa.

Wang S, Yun T, Zhu C, Li P, Ge D, Li S Ann Med. 2024; 56(1):2425072.

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The role of sarcopenic obesity for the prediction of prognosis of patients with gastrointestinal cancer.

Chen W, Yuan Q, Li X, Yao J, Yuan L, Chen X Cancer Med. 2024; 13(13):e7452.

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A population-based cohort study of longitudinal change of high-density lipoprotein cholesterol impact on gastrointestinal cancer risk.

Nam S, Jo J, Cho C Nat Commun. 2024; 15(1):2923.

PMID: 38575589 PMC: 10994902. DOI: 10.1038/s41467-024-47193-9.

Discrepant effect of high-density lipoprotein cholesterol on esophageal and gastric cancer risk in a nationwide cohort.

Nam S, Jo J, Jeon S Gastric Cancer. 2024; 27(3):451-460.

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References

Graham D, Malaty H, Evans D, Evans Jr D, KLEIN P, Adam E . Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology. 1991; 100(6):1495-501. DOI: 10.1016/0016-5085(91)90644-z. View

Lauwers G, Riddell R . Gastric epithelial dysplasia. Gut. 1999; 45(5):784-90. PMC: 1727726. DOI: 10.1136/gut.45.5.784. View

. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut. 2001; 49(3):347-53. PMC: 1728434. DOI: 10.1136/gut.49.3.347. View

Jun J, Gwack J, Park S, Choi Y, Kim Y, Shin A . [Fasting serum glucose level and gastric cancer risk in a nested case-control study]. J Prev Med Public Health. 2006; 39(6):493-8. View

Shin C, Kim N, Yang H, Cho S, Lee H, Kim J . Stomach cancer risk in gastric cancer relatives: interaction between Helicobacter pylori infection and family history of gastric cancer for the risk of stomach cancer. J Clin Gastroenterol. 2009; 44(2):e34-9. DOI: 10.1097/MCG.0b013e3181a159c4. View

Jee S, Ohrr H, Sull J, Yun J, Ji M, Samet J . Fasting serum glucose level and cancer risk in Korean men and women. JAMA. 2005; 293(2):194-202. DOI: 10.1001/jama.293.2.194. View

Yamagata H, Kiyohara Y, Nakamura S, Kubo M, Tanizaki Y, Matsumoto T . Impact of fasting plasma glucose levels on gastric cancer incidence in a general Japanese population: the Hisayama study. Diabetes Care. 2005; 28(4):789-94. DOI: 10.2337/diacare.28.4.789. View

Crawley D, Holmberg L, Melvin J, Loda M, Chowdhury S, Rudman S . Serum glucose and risk of cancer: a meta-analysis. BMC Cancer. 2014; 14:985. PMC: 4320469. DOI: 10.1186/1471-2407-14-985. View

Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M . Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001; 345(11):784-9. DOI: 10.1056/NEJMoa001999. View

10.

Di Gregorio C, Morandi P, Fante R, De Gaetani C . Gastric dysplasia. A follow-up study. Am J Gastroenterol. 1993; 88(10):1714-9. View

11.

Asaka M, Kimura T, Kudo M, Takeda H, Mitani S, Miyazaki T . Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology. 1992; 102(3):760-6. DOI: 10.1016/0016-5085(92)90156-s. View

12.

Song M, Camargo M, Weinstein S, Best A, Mannisto S, Albanes D . Family history of cancer in first-degree relatives and risk of gastric cancer and its precursors in a Western population. Gastric Cancer. 2018; 21(5):729-737. PMC: 7380686. DOI: 10.1007/s10120-018-0807-0. View

13.

Dhillon P, Farrow D, Vaughan T, Chow W, Risch H, Gammon M . Family history of cancer and risk of esophageal and gastric cancers in the United States. Int J Cancer. 2001; 93(1):148-52. DOI: 10.1002/ijc.1294. View

14.

Nam S, Ryu K, Park B, Park S . Effects of Helicobacter pylori infection and its eradication on lipid profiles and cardiovascular diseases. Helicobacter. 2014; 20(2):125-32. DOI: 10.1111/hel.12182. View

15.

Park M, Kim D, Lim S, Yim J, Kim Y, Cho K . Features of Gastric Neoplasm Detected during the Screening Examination. Gut Liver. 2010; 1(1):33-9. PMC: 2871660. DOI: 10.5009/gnl.2007.1.1.33. View

16.

Forman D, Newell D, Fullerton F, Yarnell J, Stacey A, Wald N . Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ. 1991; 302(6788):1302-5. PMC: 1670011. DOI: 10.1136/bmj.302.6788.1302. View

17.

La Vecchia C, Negri E, Franceschi S, Gentile A . Family history and the risk of stomach and colorectal cancer. Cancer. 1992; 70(1):50-5. DOI: 10.1002/1097-0142(19920701)70:1<50::aid-cncr2820700109>3.0.co;2-i. View

18.

Rocco A, Caruso R, Toracchio S, Rigoli L, Verginelli F, Catalano T . Gastric adenomas: relationship between clinicopathological findings, Helicobacter pylori infection, APC mutations and COX-2 expression. Ann Oncol. 2006; 17 Suppl 7:vii103-8. DOI: 10.1093/annonc/mdl961. View

19.

Huang J, Sridhar S, Chen Y, Hunt R . Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology. 1998; 114(6):1169-79. DOI: 10.1016/s0016-5085(98)70422-6. View

20.

Choi Y, Kim N, Jang W, Seo B, Oh S, Shin C . Familial Clustering of Gastric Cancer: A Retrospective Study Based on the Number of First-Degree Relatives. Medicine (Baltimore). 2016; 95(20):e3606. PMC: 4902404. DOI: 10.1097/MD.0000000000003606. View