Respiratory Determinants of Exercise Limitation: Focus on Phrenic Afferents and the Lung Vasculature

Overview

Journal Clin Chest Med

Specialty Pulmonary Medicine

Date 2019 May 13

PMID 31078213

Citations 9

Authors

Jerome A Dempsey

Affiliations

Soon will be listed here.

Abstract

We examine 2 means by which the healthy respiratory system contributes to exercise limitation. These include the activation of respiratory and locomotor muscle afferent reflexes, which constrain blood flow and hasten fatigue in both sets of muscles, and the excessive increases in pulmonary vascular pressures at high cardiac outputs, which constrain O transport and precipitate maladaptive right ventricular remodeling in endurance-trained subjects.

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