Cytotoxic, Anti-Migration, and Anti-Invasion Activities on Breast Cancer Cells of Angucycline Glycosides Isolated from a Marine-Derived Sp

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2019 May 12

PMID 31075906

Citations 9

Authors

Xin-Ying Qu

Jin-Wei Ren

Ai-Hong Peng

Shi-Qi Lin

Dan-Dan Lu

Qian-Qian Du

Ling Liu

Xia Li

Er-Wei Li

Wei-Dong Xie

Affiliations

Soon will be listed here.

Abstract

Four angucycline glycosides were previously characterized from marine-derived sp. OC1610.4. Further investigation of this strain cultured on different fermentation media from that used previously resulted in the isolation of two new angucycline glycosides, vineomycins E and F (-), and five known homologues, grincamycin L (), vineomycinone B (), fridamycin D (), moromycin B (), and saquayamycin B (). Vineomycin F () contains an unusual ring-cleavage deoxy sugar. All the angucycline glycosides isolated from sp. OC1610.4 were evaluated for their cytotoxic activity against breast cancer cells MCF-7, MDA-MB-231, and BT-474. Moromycin B (), saquayamycin B (), and saquayamycin B () displayed potent anti-proliferation against the tested cell lines, with IC values ranging from 0.16 to 0.67 μM. Saquayamycin B () inhibited the migration and invasion of MDA-MB-231 cells in a dose-dependent manner, as detected by Transwell and wound-healing assays.

Citing Articles

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