Immunohistochemical Demonstration of Glial Markers in Retinoblastomas

Overview

Journal Virchows Arch A Pathol Anat Histopathol

Specialty Anatomy & Histology

Date 1987 Jan 1

PMID 3107211

Citations 3

Authors

H D Schroder

Affiliations

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Abstract

Twenty retinoblastomas were studied immunohistochemically in order to visualize glial cells. In the retina, the glial cells in the ganglion cell layer and the Müller cells were GFAP positive, while only the glial cells of the ganglion cell layer expressed S-100 reactivity. In the tumours S-100/GFAP positive glial cells were found in areas near the retina and along many tumour vessels. Some S-100 reactive cells previously interpreted as tumour cells were refound in a few tumours. In areas with Flexner-Winterstein rosettes and in areas with light cells showing photoreceptor-like differentiation, glial cells reactive for both S-100 and GFAP were demonstrated. The latter findings may represent differentiation in a glial direction in the more mature parts of retinoblastoma.

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References

Mirshahi M, Boucheix C, DHERMY P, HAYE C, Faure J . Expression of the photoreceptor-specific S-antigen in human retinoblastoma. Cancer. 1986; 57(8):1497-500. DOI: 10.1002/1097-0142(19860415)57:8<1497::aid-cncr2820570810>3.0.co;2-h. View

Tso M . Clues to the cells of origin in retinoblastoma. Int Ophthalmol Clin. 1980; 20(2):191-210. View

Deck J, Eng L, Bigbee J, WOODCOCK S . The role of glial fibrillary acidic protein in the diagnosis of central nervous system tumors. Acta Neuropathol. 1978; 42(3):183-90. DOI: 10.1007/BF00690355. View

Kyritsis A, Tsokos M, Triche T, Chader G . Retinoblastoma--origin from a primitive neuroectodermal cell?. Nature. 1984; 307(5950):471-3. DOI: 10.1038/307471a0. View

Messmer E, Font R, Kirkpatrick J, HOPPING W . Immunohistochemical demonstration of neuronal and astrocytic differentiation in retinoblastoma. Ophthalmology. 1985; 92(1):167-73. DOI: 10.1016/s0161-6420(85)34076-9. View

Bonnin J, Rubinstein L . Immunohistochemistry of central nervous system tumors. Its contributions to neurosurgical diagnosis. J Neurosurg. 1984; 60(6):1121-33. DOI: 10.3171/jns.1984.60.6.1121. View

Molnar M, Stefansson K, Marton L, Tripathi R, Molnar G . Immunohistochemistry of retinoblastomas in humans. Am J Ophthalmol. 1984; 97(3):301-7. DOI: 10.1016/0002-9394(84)90627-5. View

Loeffel S, Gillespie G, Mirmiran S, Miller E, Golden P, Askin F . Cellular immunolocalization of S100 protein within fixed tissue sections by monoclonal antibodies. Arch Pathol Lab Med. 1985; 109(2):117-22. View

Takahashi K, Isobe T, Ohtsuki Y, Akagi T, Sonobe H, Okuyama T . Immunohistochemical study on the distribution of alpha and beta subunits of S-100 protein in human neoplasm and normal tissues. Virchows Arch B Cell Pathol Incl Mol Pathol. 1984; 45(4):385-96. DOI: 10.1007/BF02889881. View

10.

DUNPHY E . THE STORY OF RETINOBLASTOMA. Trans Am Acad Ophthalmol Otolaryngol. 1964; 68:249-64. View

11.

Molnar M, Stefansson K, Marton L, Tripathi R, Molnar G . Distribution of S-100 protein and glial fibrillary acidic protein in normal and gliotic human retina. Exp Eye Res. 1984; 38(1):27-34. DOI: 10.1016/0014-4835(84)90135-0. View

12.

ROESSMANN U, Velasco M, Gambetti P . Neuronal and astrocytic differentiation in human neuroepithelial neoplasms. An immunohistochemical study. J Neuropathol Exp Neurol. 1983; 42(2):113-21. DOI: 10.1097/00005072-198303000-00001. View

13.

Schroder H, Johannsen L . Demonstration of S-100 protein in sustentacular cells of phaeochromocytomas and paragangliomas. Histopathology. 1986; 10(10):1023-33. DOI: 10.1111/j.1365-2559.1986.tb02539.x. View

14.

Bignami A, Dahl D . The radial glia of Müller in the rat retina and their response to injury. An immunofluorescence study with antibodies to the glial fibrillary acidic (GFA) protein. Exp Eye Res. 1979; 28(1):63-9. DOI: 10.1016/0014-4835(79)90106-4. View

15.

Lane J, Klintworth G . A study of astrocytes in retinoblastomas using the immunoperoxidase technique and antibodies to glial fibrillary acidic protein. Am J Ophthalmol. 1983; 95(2):197-207. DOI: 10.1016/0002-9394(83)90014-4. View

16.

Terenghi G, Polak J, Ballesta J, Cocchia D, Michetti F, Dahl D . Immunocytochemistry of neuronal and glial markers in retinoblastoma. Virchows Arch A Pathol Anat Histopathol. 1984; 404(1):61-73. DOI: 10.1007/BF00704251. View

17.

Kumpulainen T, Dahl D, Korhonen L, NYSTROM S . Immunolabeling of carbonic anhydrase isoenzyme C and glial fibrillary acidic protein in paraffin-embedded tissue sections of human brain and retina. J Histochem Cytochem. 1983; 31(7):879-86. DOI: 10.1177/31.7.6406590. View

18.

Jessen K, Thorpe R, Mirsky R . Molecular identity, distribution and heterogeneity of glial fibrillary acidic protein: an immunoblotting and immunohistochemical study of Schwann cells, satellite cells, enteric glia and astrocytes. J Neurocytol. 1984; 13(2):187-200. DOI: 10.1007/BF01148114. View

19.

Nakajima T, Watanabe S, Sato Y, Kameya T, Hirota T, Shimosato Y . An immunoperoxidase study of S-100 protein distribution in normal and neoplastic tissues. Am J Surg Pathol. 1982; 6(8):715-27. DOI: 10.1097/00000478-198212000-00003. View

20.

Mannoji H, Takeshita I, Fukui M, Ohta M, Kitamura K . Glial fibrillary acidic protein in medulloblastoma. Acta Neuropathol. 1981; 55(1):63-9. DOI: 10.1007/BF00691533. View