Nonrandom Allele Associations Between Unlinked Protein Loci: Are the Polymorphisms of the Immunoglobulin Constant Regions Adaptive?

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1987 May 1

PMID 3106983

Citations 8

Authors

W van der Loo

C P Arthur

B J Richardson

R HAMERS

Affiliations

Soon will be listed here.

Abstract

Consistent linkage disequilibrium was observed between independently segregating protein loci. In natural populations of the European rabbit Oryctolagus cuniculus, highly significant, nonrandom associations between alleles of the constant regions of the immunoglobulin light and heavy chains were found, both within localities and between localities. We suggest that the population genetic data presented here are relevant to the adaptive significance of the genetic polymorphisms of the antibody constant regions.

Citing Articles

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Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids.

Pinheiro A, Lanning D, Alves P, Mage R, Knight K, van der Loo W Immunogenetics. 2011; 63(7):397-408.

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Evidence for contrasting modes of selection at interacting globin genes in the European rabbit (Oryctolagus cuniculus).

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Symbiont survival and host-symbiont disequilibria under differential vertical transmission.

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Compensatory aspects of allele diversity at immunoglobulin loci: gene correlations in rabbit populations devoid of light chain diversity (Oryctolagus cuniculus L.; Kerguelen Islands).

van der Loo W, Bousses P, Arthur C, Chapuis J Genetics. 1996; 144(3):1181-94.

PMID: 8913759 PMC: 1207610. DOI: 10.1093/genetics/144.3.1181.

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