Beneficial Effects of Rhodiola and Salidroside in Diabetes: Potential Role of AMP-Activated Protein Kinase

Overview

Journal Mol Diagn Ther

Specialties Molecular Biology
Pathology
Pharmacology

Date 2019 May 10

PMID 31069710

Citations 14

Authors

Tao Zheng

Fang Bian

Li Chen

Qibin Wang

Si Jin

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus represents a chronic metabolic disorder characterized by impaired lipid homeostasis and carbohydrate metabolism, gradually leading to persistent hyperglycemia. The extracts of Rhodiola species are widely used as herbal medicine or dietary supplement in Asia, Europe and the United States. Salidroside, a p-hydroxyphenethyl-β-glucoside compound, is the main active ingredient of the Rhodiola root. Recently, various studies have suggested that Rhodiola and salidroside may have pharmacological properties that could be used in the treatment of diabetes, as studies have confirmed that AMP-activated protein kinase (AMPK) and AMPK-related signaling are connected with its beneficial effects. This review aims to summarize the research progress of Rhodiola and salidroside in the treatment of diabetes. A detailed summary of AMPK and AMPK-related signaling induced by Rhodiola and salidroside are discussed.

Citing Articles

Recent advances in anti-inflammation via AMPK activation.

Xu Y, Bai L, Yang X, Huang J, Wang J, Wu X Heliyon. 2024; 10(13):e33670.

PMID: 39040381 PMC: 11261115. DOI: 10.1016/j.heliyon.2024.e33670.

Comprehensive machine learning models for predicting therapeutic targets in type 2 diabetes utilizing molecular and biochemical features in rats.

Matboli M, Al-Amodi H, Khaled A, Khaled R, Roushdy M, Ali M Front Endocrinol (Lausanne). 2024; 15:1384984.

PMID: 38854687 PMC: 11157016. DOI: 10.3389/fendo.2024.1384984.

The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus.

Ding W, Yang X, Lai K, Jiang Y, Liu Y Arch Pharm Res. 2024; 47(3):219-248.

PMID: 38485900 DOI: 10.1007/s12272-024-01490-5.

Phytosterols in rice bran and their health benefits.

Liu Z, Liu X, Ma Z, Guan T Front Nutr. 2023; 10:1287405.

PMID: 37899831 PMC: 10600523. DOI: 10.3389/fnut.2023.1287405.

Phenolic Compounds of L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases.

Bernatoniene J, Jakstas V, Kopustinskiene D Int J Mol Sci. 2023; 24(15).

PMID: 37569669 PMC: 10418374. DOI: 10.3390/ijms241512293.

References

Zhang J, Zhen Y, Pu-Bu-Ci-Ren , Song L, Kong W, Shao T . Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus. Behav Brain Res. 2013; 244:70-81. DOI: 10.1016/j.bbr.2013.01.037. View

Bian F, Yang X, Zhou F, Wu P, Xing S, Xu G . C-reactive protein promotes atherosclerosis by increasing LDL transcytosis across endothelial cells. Br J Pharmacol. 2014; 171(10):2671-84. PMC: 4009008. DOI: 10.1111/bph.12616. View

Dikic I, Elazar Z . Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol. 2018; 19(6):349-364. DOI: 10.1038/s41580-018-0003-4. View

Zhang Y, Guo H, Zhang C, Lin S, Yin Z, Peng Y . AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metab. 2013; 18(4):546-55. DOI: 10.1016/j.cmet.2013.09.005. View

Jiao L, Zhang X, Huang L, Gong H, Cheng B, Sun Y . Proanthocyanidins are the major anti-diabetic components of cinnamon water extract. Food Chem Toxicol. 2013; 56:398-405. DOI: 10.1016/j.fct.2013.02.049. View

Garcia D, Shaw R . AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance. Mol Cell. 2017; 66(6):789-800. PMC: 5553560. DOI: 10.1016/j.molcel.2017.05.032. View

Xing S, Yang X, Zheng T, Li W, Wu D, Chi J . Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway. Vascul Pharmacol. 2015; 72:141-52. DOI: 10.1016/j.vph.2015.07.004. View

Ma Y, Wang J, Zhang Y, Wang B, Dai Z, Xie M . Salidroside improved cerebrovascular vasodilation in streptozotocin-induced diabetic rats through restoring the function of BK channel in smooth muscle cells. Cell Tissue Res. 2017; 370(3):365-377. DOI: 10.1007/s00441-017-2671-3. View

Chen J, Zhang N, Mao G, He X, Zhan Y, Deng H . Salidroside stimulates osteoblast differentiation through BMP signaling pathway. Food Chem Toxicol. 2013; 62:499-505. DOI: 10.1016/j.fct.2013.09.019. View

10.

Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y . Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004; 114(12):1752-61. PMC: 535065. DOI: 10.1172/JCI21625. View

11.

Li H, Ge Y, Zheng X, Zhang L . Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol. 2008; 588(2-3):165-9. DOI: 10.1016/j.ejphar.2008.04.036. View

12.

Qian E, Ge D, Kong S . Salidroside promotes erythropoiesis and protects erythroblasts against oxidative stress by up-regulating glutathione peroxidase and thioredoxin. J Ethnopharmacol. 2010; 133(2):308-14. DOI: 10.1016/j.jep.2010.09.025. View

13.

Booker A, Jalil B, Frommenwiler D, Reich E, Zhai L, Kulic Z . The authenticity and quality of Rhodiola rosea products. Phytomedicine. 2015; 23(7):754-62. DOI: 10.1016/j.phymed.2015.10.006. View

14.

Kelly G . Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001; 6(3):293-302. View

15.

Wu D, Yang X, Zheng T, Xing S, Wang J, Chi J . A novel mechanism of action for salidroside to alleviate diabetic albuminuria: effects on albumin transcytosis across glomerular endothelial cells. Am J Physiol Endocrinol Metab. 2015; 310(3):E225-37. DOI: 10.1152/ajpendo.00391.2015. View

16.

Guariguata L, Whiting D, Hambleton I, Beagley J, Linnenkamp U, Shaw J . Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014; 103(2):137-49. DOI: 10.1016/j.diabres.2013.11.002. View

17.

Dun Y, Liu S, Zhang W, Xie M, Qiu L . Exercise Combined with Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control. Oxid Med Cell Longev. 2018; 2017:8024857. PMC: 5735688. DOI: 10.1155/2017/8024857. View

18.

Zimmet P, Alberti K, Shaw J . Global and societal implications of the diabetes epidemic. Nature. 2001; 414(6865):782-7. DOI: 10.1038/414782a. View

19.

Grech-Baran M, Syklowska-Baranek K, Pietrosiuk A . Biotechnological approaches to enhance salidroside, rosin and its derivatives production in selected spp. in vitro cultures. Phytochem Rev. 2015; 14(4):657-674. PMC: 4513219. DOI: 10.1007/s11101-014-9368-y. View

20.

Saltiel A, Kahn C . Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001; 414(6865):799-806. DOI: 10.1038/414799a. View