MT1-MMP-dependent Cell Migration: Proteolytic and Non-proteolytic Mechanisms

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2019 May 9

PMID 31064864

Citations 43

Authors

Valentina Gifford

Yoshifumi Itoh

Affiliations

Soon will be listed here.

Abstract

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety of cell types both in physiological and pathological conditions. It promotes cell migration by degrading extracellular matrix on the cell surface and creates a migration path, by modifying cell adhesion property by shedding cell adhesion molecules to increase cell motility, and by altering cellular metabolism. Thus, MT1-MMP is a multifunctional cell motility enhancer. In this review, we will discuss the current understanding of the proteolytic and non-proteolytic mechanism of MT1-MMP-dependent cell migration.

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