Genomic Analysis of a Novel Nontoxigenic Strain Isolated from a Cancer Patient

Overview

Journal New Microbes New Infect

Publisher Elsevier

Specialty Infectious Diseases

Date 2019 May 8

PMID 31061711

Citations 1

Authors

N D Ramdhan

J Blom

I C Sutcliffe

P M A Pereira-Ribeiro

C S Santos

A L Mattos-Guaraldi

A Burkovski

V Sangal

Affiliations

Soon will be listed here.

Abstract

The genome of a novel nontoxigenic strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses -type and -type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.

Citing Articles

Whole genome sequence of a non-toxigenic Corynebacterium diphtheriae strain from a hospital in southeastern China.

Li G, Wang S, Zhao S, Zhou Y, Pan X BMC Genom Data. 2021; 22(1):42.

PMID: 34656079 PMC: 8520229. DOI: 10.1186/s12863-021-00998-9.

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