Connecting Iron Acquisition and Biofilm Formation in the ESKAPE Pathogens As a Strategy for Combatting Antibiotic Resistance

Overview

Journal Medchemcomm

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2019 May 7

PMID 31057729

Citations 17

Authors

Savannah J Post

Justin A Shapiro

William M Wuest

Affiliations

Soon will be listed here.

Abstract

The rise of antibiotic resistant bacteria has become a problem of global concern. Of particular interest are the ESKAPE pathogens, species with high rates of multi-drug resistant infections. Novel antibiotic mechanisms of action are necessary to compliment traditional therapeutics. Recent research has focused on targeting virulence factors as a method of combatting infection without creating selective pressure for resistance or damaging the host commensal microbiome. Some investigations into one such virulence behavior, iron acquisition, have displayed additional effects on another virulence behavior, biofilm formation. The use of exogenous iron-chelators, gallium as an iron mimic, and inhibition of siderophore-mediated iron acquisition are all strategies for disturbing iron-homeostasis that have implicated effects on biofilms. However, the exact nature of this connection remains ambiguous. Herein we summarize these findings and identify opportunities for further investigation.

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References

Lipsitch M, Samore M . Antimicrobial use and antimicrobial resistance: a population perspective. Emerg Infect Dis. 2002; 8(4):347-54. PMC: 2730242. DOI: 10.3201/eid0804.010312. View

Bernstein L . Mechanisms of therapeutic activity for gallium. Pharmacol Rev. 1998; 50(4):665-82. View

Meyer J, Neely A, Stintzi A, Georges C, Holder I . Pyoverdin is essential for virulence of Pseudomonas aeruginosa. Infect Immun. 1996; 64(2):518-23. PMC: 173795. DOI: 10.1128/iai.64.2.518-523.1996. View

Yatsunenko T, Rey F, Manary M, Trehan I, Dominguez-Bello M, Contreras M . Human gut microbiome viewed across age and geography. Nature. 2012; 486(7402):222-7. PMC: 3376388. DOI: 10.1038/nature11053. View

Garcia-Quintanilla M, Pulido M, Lopez-Rojas R, Pachon J, McConnell M . Emerging therapies for multidrug resistant Acinetobacter baumannii. Trends Microbiol. 2013; 21(3):157-63. DOI: 10.1016/j.tim.2012.12.002. View

Moreau-Marquis S, OToole G, Stanton B . Tobramycin and FDA-approved iron chelators eliminate Pseudomonas aeruginosa biofilms on cystic fibrosis cells. Am J Respir Cell Mol Biol. 2009; 41(3):305-13. PMC: 2742750. DOI: 10.1165/rcmb.2008-0299OC. View

Russo T, Shon A, Beanan J, Olson R, MacDonald U, Pomakov A . Hypervirulent K. pneumoniae secretes more and more active iron-acquisition molecules than "classical" K. pneumoniae thereby enhancing its virulence. PLoS One. 2011; 6(10):e26734. PMC: 3200348. DOI: 10.1371/journal.pone.0026734. View

Lamont I, Beare P, Ochsner U, Vasil A, Vasil M . Siderophore-mediated signaling regulates virulence factor production in Pseudomonasaeruginosa. Proc Natl Acad Sci U S A. 2002; 99(10):7072-7. PMC: 124530. DOI: 10.1073/pnas.092016999. View

Gould I . Treatment of bacteraemia: meticillin-resistant Staphylococcus aureus (MRSA) to vancomycin-resistant S. aureus (VRSA). Int J Antimicrob Agents. 2013; 42 Suppl:S17-21. DOI: 10.1016/j.ijantimicag.2013.04.006. View

10.

Bragg R, Meyburgh C, Lee J, Coetzee M . Potential Treatment Options in a Post-antibiotic Era. Adv Exp Med Biol. 2018; 1052:51-61. DOI: 10.1007/978-981-10-7572-8_5. View

11.

Eijkelkamp B, Hassan K, Paulsen I, Brown M . Investigation of the human pathogen Acinetobacter baumannii under iron limiting conditions. BMC Genomics. 2011; 12:126. PMC: 3055841. DOI: 10.1186/1471-2164-12-126. View

12.

Banin E, Lozinski A, Brady K, Berenshtein E, Butterfield P, Moshe M . The potential of desferrioxamine-gallium as an anti-Pseudomonas therapeutic agent. Proc Natl Acad Sci U S A. 2008; 105(43):16761-6. PMC: 2575493. DOI: 10.1073/pnas.0808608105. View

13.

Kaneko Y, Thoendel M, Olakanmi O, Britigan B, Singh P . The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity. J Clin Invest. 2007; 117(4):877-88. PMC: 1810576. DOI: 10.1172/JCI30783. View

14.

Garcia R, Tennent D, Chang D, Wenke J, Sanchez Jr C . An In Vitro Comparison of PMMA and Calcium Sulfate as Carriers for the Local Delivery of Gallium(III) Nitrate to Staphylococcal Infected Surgical Sites. Biomed Res Int. 2016; 2016:7078989. PMC: 4739006. DOI: 10.1155/2016/7078989. View

15.

Alvarez-Ortega C, Wiegand I, Olivares J, Hancock R, Luis Martinez J . The intrinsic resistome of Pseudomonas aeruginosa to β-lactams. Virulence. 2011; 2(2):144-6. DOI: 10.4161/viru.2.2.15014. View

16.

Johnson M, Cockayne A, Morrissey J . Iron-regulated biofilm formation in Staphylococcus aureus Newman requires ica and the secreted protein Emp. Infect Immun. 2008; 76(4):1756-65. PMC: 2292859. DOI: 10.1128/IAI.01635-07. View

17.

Bullen J, Rogers H, Spalding P, Ward C . Iron and infection: the heart of the matter. FEMS Immunol Med Microbiol. 2005; 43(3):325-30. DOI: 10.1016/j.femsim.2004.11.010. View

18.

Chitambar C . Medical applications and toxicities of gallium compounds. Int J Environ Res Public Health. 2010; 7(5):2337-61. PMC: 2898053. DOI: 10.3390/ijerph7052337. View

19.

Ley R, Turnbaugh P, Klein S, Gordon J . Microbial ecology: human gut microbes associated with obesity. Nature. 2006; 444(7122):1022-3. DOI: 10.1038/4441022a. View

20.

de Chial M, Ghysels B, Beatson S, Geoffroy V, Meyer J, Pattery T . Identification of type II and type III pyoverdine receptors from Pseudomonas aeruginosa. Microbiology (Reading). 2003; 149(Pt 4):821-831. DOI: 10.1099/mic.0.26136-0. View