Exploring Cellular Stress Response and Chaperones

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2019 May 5

PMID 31052568

Citations 7

Authors

Alessandra Stacchiotti

Affiliations

Soon will be listed here.

Abstract

Since the pioneering discovery of heat shock proteins in by Ferruccio Ritossa in 1960s, a long and exciting journey has been undertaken by molecular biologists and researchers worldwide. Not only lower organisms like worms, yeast, amoeba, and flies but also eukaryotes share common cellular response signals to stressful conditions that can arise from the outside but also from the inside. Moreover, extraordinary interplay between nucleus and subcellular organelles, and between different organelles, like mitochondria and the endoplasmic reticulum called mitochondria-associated endoplasmic reticulum membranes (MAMs), are involved in aging and human diseases like obesity, diabetes, inflammation, neurodegeneration, autoimmune diseases, atherosclerosis, and cancer. Actually, we know that to hit abnormal proteostasis and lipid exchanges in the endoplasmic reticulum is crucial to best guide effective therapies or discover new drugs. Indeed, restoration or impairment of endoplasmic reticulum shape and function lead to cellular homeostasis by autophagy or to final death generally by apoptosis or pyroptosis. This Special Issue collects current valuable articles or reviews on cellular stress research and each contribution opens a new window for further studies and hypothesis. I hope that readers interested in this fascinating topic may be stimulated to know more and more.

Citing Articles

Genomic disturbance of vitellogenin 2 (vtg2) leads to vitellin membrane deficiencies and significant mortalities at early stages of embryonic development in zebrafish (Danio rerio).

Yilmaz O, Com E, Pineau C, Bobe J Sci Rep. 2023; 13(1):18795.

PMID: 37914813 PMC: 10620220. DOI: 10.1038/s41598-023-46148-2.

Potential of the Signal Peptide Derived from the Gene Product for Secretory Expression of Valuable Enzymes in .

Shen Q, Zhou X, Guo Q, Xue Y, Xue Y, Zheng Y Appl Environ Microbiol. 2022; 88(9):e0029622.

PMID: 35435711 PMC: 9088389. DOI: 10.1128/aem.00296-22.

Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Stage Transition under Temperature Stress in Synchronized Plasmodium falciparum Cells.

Rawat M, Srivastava A, Johri S, Gupta I, Karmodiya K Microbiol Spectr. 2021; 9(1):e0000821.

PMID: 34232098 PMC: 8552519. DOI: 10.1128/Spectrum.00008-21.

Exploring the molecular content of CHO exosomes during bioprocessing.

Keysberg C, Hertel O, Schelletter L, Busche T, Sochart C, Kalinowski J Appl Microbiol Biotechnol. 2021; 105(9):3673-3689.

PMID: 33937930 PMC: 8102462. DOI: 10.1007/s00253-021-11309-8.

Knock out of specific maternal vitellogenins in zebrafish (Danio rerio) evokes vital changes in egg proteomic profiles that resemble the phenotype of poor quality eggs.

Yilmaz O, Patinote A, Com E, Pineau C, Bobe J BMC Genomics. 2021; 22(1):308.

PMID: 33910518 PMC: 8082894. DOI: 10.1186/s12864-021-07606-1.

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