Calcium-Binding Proteins As Determinants of Central Nervous System Neuronal Vulnerability to Disease

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 May 5

PMID 31052285

Citations 44

Authors

Richard Fairless

Sarah K Williams

Ricarda Diem

Affiliations

Soon will be listed here.

Abstract

Neuronal subpopulations display differential vulnerabilities to disease, but the factors that determine their susceptibility are poorly understood. Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important first line of defense through their ability to buffer incoming calcium, allowing the neuron to quickly achieve homeostasis. Since neurons expressing different calcium-binding proteins have been reported to be differentially susceptible to degeneration, it can be hypothesized that rather than just serving as markers of different neuronal subpopulations, they might actually be a key determinant of survival. In this review, we will summarize some of the evidence that expression of the EF-hand calcium-binding proteins, calbindin, calretinin and parvalbumin, may influence the susceptibility of distinct neuronal subpopulations to disease processes.

Citing Articles

EEG Abnormalities and Phenotypic Correlates in Preschoolers with Autism Spectrum Disorder: A Single-Center Study.

Ferrini L, Bartolini E, Mancini A, Tancredi R, Ferrari A, Calderoni S J Clin Med. 2025; 14(2).

PMID: 39860535 PMC: 11766335. DOI: 10.3390/jcm14020529.

Calcium Transport and Enrichment in Microorganisms: A Review.

Zhou H, Hu Y, Tang Z, Jiang Z, Huang J, Zhang T Foods. 2024; 13(22).

PMID: 39594028 PMC: 11593130. DOI: 10.3390/foods13223612.

SMOC1 colocalizes with Alzheimer's disease neuropathology and delays Aβ aggregation.

Balcomb K, Johnston C, Kavanagh T, Leitner D, Schneider J, Halliday G Acta Neuropathol. 2024; 148(1):72.

PMID: 39585417 PMC: 11588930. DOI: 10.1007/s00401-024-02819-6.

The relationship between adult hippocampal neurogenesis and cognitive impairment in Alzheimer's disease.

Geigenmuller J, Tari A, Wisloff U, Walker T Alzheimers Dement. 2024; 20(10):7369-7383.

PMID: 39166771 PMC: 11485317. DOI: 10.1002/alz.14179.

Loss of Mitochondrial Tusc2/Fus1 Triggers a Brain Pro-Inflammatory Microenvironment and Early Spatial Memory Impairment.

Farris T, Gonzalez-Ochoa S, Mohammed M, Rajakaruna H, Tonello J, Kanagasabai T Int J Mol Sci. 2024; 25(13).

PMID: 39000512 PMC: 11242373. DOI: 10.3390/ijms25137406.

References

Przybyszewska M, Kuznicki J . Measurements of [Ca2+] using fura-2 in glioma C6 cells expressing calretinin with GFP as a marker of transfection: no Ca2+-buffering provided by calretinin. Biochim Biophys Acta. 1999; 1449(2):169-77. DOI: 10.1016/s0167-4889(99)00010-5. View

Lim J, Brunjes P . Calcium-binding proteins: differential expression in the rat olfactory cortex after neonatal olfactory bulbectomy. J Neurobiol. 1999; 39(2):207-17. DOI: 10.1002/(sici)1097-4695(199905)39:2<207::aid-neu5>3.0.co;2-c. View

Phillips R, Meier T, Giuli L, McLaughlin J, Ho D, Sapolsky R . Calbindin D28K gene transfer via herpes simplex virus amplicon vector decreases hippocampal damage in vivo following neurotoxic insults. J Neurochem. 1999; 73(3):1200-5. DOI: 10.1046/j.1471-4159.1999.0731200.x. View

Haeseleer F, Sokal I, Verlinde C, Erdjument-Bromage H, Tempst P, Pronin A . Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem. 2000; 275(2):1247-60. PMC: 1364469. DOI: 10.1074/jbc.275.2.1247. View

Kim B, Shin D, Jeon G, Seo J, Kim Y, Jeon B . Relative sparing of calretinin containing neurons in the substantia nigra of 6-OHDA treated rat parkinsonian model. Brain Res. 2000; 855(1):162-5. DOI: 10.1016/s0006-8993(99)02374-4. View

Hack N, Wride M, Charters K, Kater S, Parks T . Developmental changes in the subcellular localization of calretinin. J Neurosci. 2000; 20(7):RC67. PMC: 6772258. View

Bouilleret V, Schwaller B, Schurmans S, Celio M, Fritschy J . Neurodegenerative and morphogenic changes in a mouse model of temporal lobe epilepsy do not depend on the expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin. Neuroscience. 2000; 97(1):47-58. DOI: 10.1016/s0306-4522(00)00017-8. View

Fiumelli H, Kiraly M, Ambrus A, Magistretti P, Martin J . Opposite regulation of calbindin and calretinin expression by brain-derived neurotrophic factor in cortical neurons. J Neurochem. 2000; 74(5):1870-7. DOI: 10.1046/j.1471-4159.2000.0741870.x. View

Araki C, Hamassaki-Britto D . Calretinin co-localizes with the NMDA receptor subunit NR1 in cholinergic amacrine cells of the rat retina. Brain Res. 2000; 869(1-2):220-4. DOI: 10.1016/s0006-8993(00)02364-7. View

10.

Corns R, Boolaky U, Santer R . Decreased calbindin-D28k immunoreactivity in aged rat sympathetic pelvic ganglionic neurons. Neurosci Lett. 2000; 292(2):91-4. DOI: 10.1016/s0304-3940(00)01442-7. View

11.

DOrlando C, Fellay B, Schwaller B, Salicio V, Bloc A, Gotzos V . Calretinin and calbindin D-28k delay the onset of cell death after excitotoxic stimulation in transfected P19 cells. Brain Res. 2001; 909(1-2):145-58. DOI: 10.1016/s0006-8993(01)02671-3. View

12.

Laube G, Seidenbecher C, Richter K, Dieterich D, Hoffmann B, Landwehr M . The neuron-specific Ca2+-binding protein caldendrin: gene structure, splice isoforms, and expression in the rat central nervous system. Mol Cell Neurosci. 2002; 19(3):459-75. DOI: 10.1006/mcne.2001.1078. View

13.

Van Den Bosch L, Schwaller B, Vleminckx V, Meijers B, Stork S, Ruehlicke T . Protective effect of parvalbumin on excitotoxic motor neuron death. Exp Neurol. 2002; 174(2):150-61. DOI: 10.1006/exnr.2001.7858. View

14.

Zhang Z, Sun J, Reynolds G . A selective reduction in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia patients. Chin Med J (Engl). 2002; 115(6):819-23. View

15.

DOrlando C, Celio M, Schwaller B . Calretinin and calbindin D-28k, but not parvalbumin protect against glutamate-induced delayed excitotoxicity in transfected N18-RE 105 neuroblastoma-retina hybrid cells. Brain Res. 2002; 945(2):181-90. DOI: 10.1016/s0006-8993(02)02753-1. View

16.

Rapp P, Deroche P, Mao Y, Burwell R . Neuron number in the parahippocampal region is preserved in aged rats with spatial learning deficits. Cereb Cortex. 2002; 12(11):1171-9. DOI: 10.1093/cercor/12.11.1171. View

17.

Bu J, Sathyendra V, Nagykery N, Geula C . Age-related changes in calbindin-D28k, calretinin, and parvalbumin-immunoreactive neurons in the human cerebral cortex. Exp Neurol. 2003; 182(1):220-31. DOI: 10.1016/s0014-4886(03)00094-3. View

18.

Schwaller B, Meyer M, Schiffmann S . 'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice. Cerebellum. 2003; 1(4):241-58. DOI: 10.1080/147342202320883551. View

19.

Freund T, Ylinen A, Miettinen R, Pitkanen A, Lahtinen H, Baimbridge K . Pattern of neuronal death in the rat hippocampus after status epilepticus. Relationship to calcium binding protein content and ischemic vulnerability. Brain Res Bull. 1992; 28(1):27-38. DOI: 10.1016/0361-9230(92)90227-o. View

20.

German D, Manaye K, Sonsalla P, Brooks B . Midbrain dopaminergic cell loss in Parkinson's disease and MPTP-induced parkinsonism: sparing of calbindin-D28k-containing cells. Ann N Y Acad Sci. 1992; 648:42-62. DOI: 10.1111/j.1749-6632.1992.tb24523.x. View