Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for High or Low Inflammatory Response

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2019 May 4

PMID 31049358

Citations 3

Authors

Lilian Rego de Carvalho

Andrea Borrego

Jose Ricardo Jensen

Wafa Hanna Koury Cabrera

Aline Marques Santos

Orlando Garcia Ribeiro

Nancy Starobinas

Marcelo de Franco

Tommaso A Dragani

Giacomo Manenti

Olga Celia Martinez Ibanez

Affiliations

Soon will be listed here.

Abstract

AIRmax and AIRmin mouse strains phenotypically selected for high and low acute inflammatory responsiveness (AIR) are, respectively, susceptible or resistant to developing hepatocellular carcinoma (HCC) induced by the chemical carcinogens urethane and diethylnitrosamine (DEN). Early production of TNF-, IL-1, and IL-6 in the liver after DEN treatment correlated with tumor development in AIRmax mice. Transcriptome analysis of livers from untreated AIRmax and AIRmin mice showed specific gene expression profiles in each line, which might play a role in their differential susceptibility to HCC. Linkage analysis with SNP markers in F2 (AIRmax×AIRmin) intercross mice revealed two quantitative trait loci (QTL) in chromosomes 2 and 9, which are significantly associated with the number and progression of urethane-induced liver tumors. An independent linkage analysis with an intercross population from A/J and C57BL/6J inbred mice mapped regions in chromosomes 1 and 7 associated with the progression of urethane-induced liver tumors, evidencing the heterogeneity of HCC genetic control.

Citing Articles

Genetic Predisposition to Hepatocellular Carcinoma.

Pascale R, Calvisi D, Feo F, Simile M Metabolites. 2023; 13(1).

PMID: 36676960 PMC: 9864136. DOI: 10.3390/metabo13010035.

and Candidate Genes of Locus Modulate Inflammasome Activation for IL-1β Production.

Borrego A, Colombo F, de Souza J, Jensen J, Dassano A, Piazza R Front Immunol. 2022; 13:899569.

PMID: 35799794 PMC: 9254735. DOI: 10.3389/fimmu.2022.899569.

Mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains.

Borrego A, Jensen J, Koury Cabrera W, Massa S, Ribeiro O, Starobinas N Genes Immun. 2021; 23(1):23-32.

PMID: 34966170 PMC: 8866122. DOI: 10.1038/s41435-021-00159-z.

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