Age-related Differences in Plasmalogen Content of Erythrocytes from Patients with the Cerebro-hepato-renal (Zellweger) Syndrome: Implications for Postnatal Detection of the Disease

Overview

Journal J Inherit Metab Dis

Publisher Wiley

Date 1986 Jan 1

PMID 3104670

Citations 9

Authors

R J Wanders

Y R Purvis

H S Heymans

J A BAKKEREN

G G Parmentier

J Van Eldere

H EYSSEN

H van den Bosch

J M Tager

R B Schutgens

Affiliations

Soon will be listed here.

Abstract

Phosphatidylethanolamine plasmalogen levels were determined in erythrocytes from controls and 13 patients with the cerebro-hepato-renal (Zellweger) syndrome. It was found that in Zellweger patients 20 weeks of age or younger, erythrocyte phosphatidylethanolamine plasmalogen levels were lowered whereas in older patients (except in one) normal levels were found. The results obtained suggest a close relationship between the age of the patients at sampling and the phosphatidylethanolamine plasmalogen levels in their erythrocytes. A possible explanation for these findings and the implications for the postnatal detection of Zellweger syndrome are discussed.

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