The Level of Krüppel-like Factor 8 Expression Predicts Prognosis and Metastasis in Various Carcinomas

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2019 May 3

PMID 31045845

Citations 2

Authors

Jun Liu

Huimin Zheng

Yangyang Ding

Manman Li

Jingrong Li

Jiaojiao Guo

Linhui Hu

Lianfang Pu

Shudao Xiong

Affiliations

Soon will be listed here.

Abstract

Background And Objective: Krüppel-like factor 8 (KLF8), a transcription factor, belongs to the KLF8 family. Currently, studies have shown that KLF8 is highly expressed in some tumors. However, the prognostic value and metastasis of KLF8 in cancers remain unclear. For the first time, we conducted meta-analysis to explore the relationship between KLF8 expression with prognosis and metastasis in various carcinomas patients.

Methods: Web of Science, PubMed, Embase, and Cochrane Library were systematically searched for eligible articles. Pooled hazard ratios (HRs) and their 95% confidence intervals (95% CIs) were calculated to evaluate the prognostic value and metastasis of KLF8 expression in human cancer patients.

Results: The result revealed that highly expression level of KLF8 was significantly associated with poor overall survival (OS) (HR = 1.56, 95% CI: 1.26-1.87). Meanwhile, this significant correlation was also observed in subgroup analysis stratified by cancer types, source of HR, sample size, follow-up (months). In addition, highly expression of KLF8 was also closely associated with metastasis (HR = 1.37, 95% CI: 0.57-2.17) and tumor node metastasis stage (HR = 1.58, 95% CI: 0.90-2.25) in carcinomas.

Conclusion: In summary, our meta-analysis indicates that overexpression of KLF8 may be associated with poor prognosis and higher incidence of metastasis in various carcinomas, and KLF8 may be used as a prognostic and metastatic indicator in human cancers.

Citing Articles

SP and KLF Transcription Factors in Cancer Metabolism.

Orzechowska-Licari E, LaComb J, Mojumdar A, Bialkowska A Int J Mol Sci. 2022; 23(17).

PMID: 36077352 PMC: 9456310. DOI: 10.3390/ijms23179956.

Circulating Tumor Cells Expressing Krüppel-Like Factor 8 and Vimentin as Predictors of Poor Prognosis in Pancreatic Cancer Patients.

Zhu P, Liu H, Liu F, Gu F, Yuan S, Huang J Cancer Control. 2021; 28:10732748211027163.

PMID: 34378430 PMC: 8361509. DOI: 10.1177/10732748211027163.

References

Yi X, Zai H, Long X, Wang X, Li W, Li Y . Krüppel-like factor 8 induces epithelial-to-mesenchymal transition and promotes invasion of pancreatic cancer cells through transcriptional activation of four and a half LIM-only protein 2. Oncol Lett. 2017; 14(4):4883-4889. PMC: 5594250. DOI: 10.3892/ol.2017.6734. View

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009; 62(10):e1-34. DOI: 10.1016/j.jclinepi.2009.06.006. View

Pearson R, Fleetwood J, Eaton S, Crossley M, Bao S . Krüppel-like transcription factors: a functional family. Int J Biochem Cell Biol. 2007; 40(10):1996-2001. DOI: 10.1016/j.biocel.2007.07.018. View

Liu N, Wang Y, Zhou Y, Pang H, Zhou J, Qian P . Krüppel-like factor 8 involved in hypoxia promotes the invasion and metastasis of gastric cancer via epithelial to mesenchymal transition. Oncol Rep. 2014; 32(6):2397-404. DOI: 10.3892/or.2014.3495. View

Zeng X, Zhang Y, Kwong J, Zhang C, Li S, Sun F . The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med. 2015; 8(1):2-10. DOI: 10.1111/jebm.12141. View

Higgins J, Thompson S . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186. View

Liu Y, Yao X, Zhang Q, Qian L, Feng J, Bian T . Expression of Kruppel-like factor 8 and Ki67 in lung adenocarcinoma and prognosis. Exp Ther Med. 2017; 14(2):1351-1356. PMC: 5526062. DOI: 10.3892/etm.2017.4632. View

Hsu L, Wu P, Yeh K, Yeh C, Shen K, Chen C . Positive nuclear expression of KLF8 might be correlated with shorter survival in gastric adenocarcinoma. Ann Diagn Pathol. 2014; 18(2):74-7. DOI: 10.1016/j.anndiagpath.2013.12.001. View

Bieker J . Krüppel-like factors: three fingers in many pies. J Biol Chem. 2001; 276(37):34355-8. DOI: 10.1074/jbc.R100043200. View

10.

Miller K, Siegel R, Lin C, Mariotto A, Kramer J, Rowland J . Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016; 66(4):271-89. DOI: 10.3322/caac.21349. View

11.

Li J, Liu Y, Xue J, Xu M, Zhang J, Liu J . Krüppel-Like Factor 8 Overexpression Correlates with Poor Prognosis in Non-Small Cell Lung Cancer. Pathol Oncol Res. 2017; 25(1):115-121. DOI: 10.1007/s12253-017-0321-4. View

12.

Mukherjee D, Lu H, Yu L, He C, Lahiri S, Li T . Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis. Oncotarget. 2016; 7(17):23552-68. PMC: 5029647. DOI: 10.18632/oncotarget.8083. View

13.

Tierney J, Stewart L, Ghersi D, Burdett S, Sydes M . Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 2007; 8:16. PMC: 1920534. DOI: 10.1186/1745-6215-8-16. View

14.

Wu S, Powers S, Zhu W, Hannun Y . Substantial contribution of extrinsic risk factors to cancer development. Nature. 2015; 529(7584):43-7. PMC: 4836858. DOI: 10.1038/nature16166. View

15.

Wei Y, Chen G, You L, Zhao Y . Krüpel-like factor 8 is a potential prognostic factor for pancreatic cancer. Chin Med J (Engl). 2014; 127(5):856-9. View

16.

Lee H, Kim H, Lee Y, Lee M, Choi H, Lee H . Krüppel-like factor KLF8 plays a critical role in adipocyte differentiation. PLoS One. 2013; 7(12):e52474. PMC: 3528641. DOI: 10.1371/journal.pone.0052474. View

17.

van Vliet J, Turner J, Crossley M . Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. Nucleic Acids Res. 2000; 28(9):1955-62. PMC: 103308. DOI: 10.1093/nar/28.9.1955. View

18.

Chen W, Zheng R, Baade P, Zhang S, Zeng H, Bray F . Cancer statistics in China, 2015. CA Cancer J Clin. 2016; 66(2):115-32. DOI: 10.3322/caac.21338. View

19.

Wang W, Li J, Du L, Wang L, Yang Y, Liu Y . Krüppel-like factor 8 overexpression is correlated with angiogenesis and poor prognosis in gastric cancer. World J Gastroenterol. 2013; 19(27):4309-15. PMC: 3718898. DOI: 10.3748/wjg.v19.i27.4309. View

20.

Yan Q, Zhang W, Wu Y, Wu M, Zhang M, Shi X . KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2. Oncotarget. 2015; 6(28):25402-17. PMC: 4694840. DOI: 10.18632/oncotarget.4517. View