Association of Glucose and Blood Pressure Variability on Oxidative Stress in Patients with Type 2 Diabetes Mellitus and Hypertension: a Cross-sectional Study

Overview

Journal Diabetol Metab Syndr

Publisher Biomed Central

Specialty Endocrinology

Date 2019 May 3

PMID 31044019

Citations 12

Authors

Makoto Ohara

Yo Kohata

Hiroe Nagaike

Masakazu Koshibu

Hiroya Gima

Munenori Hiromura

Takeshi Yamamoto

Yusaku Mori

Toshiyuki Hayashi

Tomoyasu Fukui

Tsutomu Hirano

Affiliations

Soon will be listed here.

Abstract

Background: The present study evaluated the effects of glucose and blood pressure (BP) variability on oxidative stress in patients with type 2 diabetes mellitus (T2DM) and hypertension.

Methods: A total of 60 inpatients with T2DM underwent continuous glucose monitoring (CGM) and ambulatory BP monitoring (ABPM). Oxidative stress was estimated using the diacron-reactive oxygen metabolites (d-ROMs) test. Glucose variability, mean glucose level, percentage coefficient of variation for glucose, mean amplitude of glycemic excursions (MAGE), and area under the postprandial plasma glucose curve were determined through CGM. BP variability was assessed by measuring average BP, standard deviation (SD) of systolic and diastolic BP, and coefficient of variation (CV) of systolic and diastolic BP during daytime and nighttime ABPM.

Results: Participants had a mean age of 64.5 ± 13.3 years with the duration of the disease 13.9 ± 12.4 years and HbA1c of 8.5 ± 1.2%. Univariate analysis showed that MAGE, nighttime SDs of systolic and diastolic BP, and nighttime CV of systolic BP were significantly correlated with d-ROMs. Further, stepwise multiple regression analysis identified MAGE, nighttime SD and CV of diastolic BP, estimated glomerular filtration rate, and smoking as independent contributors to d-ROMs.

Conclusions: Oxidative stress was associated with daily glucose and nighttime diastolic BP variability in patients with T2DM and hypertension. UMIN Clinical Trial Registry UMIN000035615, Registered January 22, 2019-retrospectively registered.

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