Short Stature-related Single-nucleotide Polymorphism (SNP) Activates Endothelial Repair Activity in Elderly Japanese

Overview

Journal Environ Health Prev Med

Specialties Environmental Health
Public Health

Date 2019 May 3

PMID 31043174

Citations 6

Authors

Yuji Shimizu

Hirotomo Yamanashi

Yuko Noguchi

Jun Koyamatsu

Mako Nagayoshi

Kairi Kiyoura

Shoichi Fukui

Mami Tamai

Shin-Ya Kawashiri

Kazuhiko Arima

Takahiro Maeda

Affiliations

Soon will be listed here.

Abstract

Background: Hypertension and atherosclerosis are bidirectionally related, while platelet count could serve as an indicator of endothelial repair. Therefore, high platelet counts could be associated with hypertension by indicating more intense endothelial repair activity. Furthermore, short stature has been shown to constitute a risk of atherosclerosis. Since inflammation-related single-nucleotide polymorphism (SNP (rs3782886)) is reportedly associated with myocardial infarction and short stature, rs3782886 could be associated with a high platelet count and thus more intense endothelial repair activity.

Methods: We conducted a cross-sectional study of 988 elderly Japanese who participated in a general health check-up. Short stature was defined as a height of at or under the 25th percentile of the study population, and high platelet count as the highest tertiles of the platelet levels.

Results: High platelet counts were found to be independently and positively associated with hypertension while rs3782886 was independently associated with high platelet levels and short stature. The classical cardiovascular risk factor-adjusted odds ratio (OR) and 95% confidence interval (CI) of high platelet count for hypertension was 1.34 (1.02, 1.77). With non-minor homo of the rs3782886 as the reference group, the adjusted OR and 95% CI for high platelet count and short stature of minor home were 2.40 (1.30, 4.42) and 2.21 (1.16, 4.21), respectively.

Conclusion: SNP (rs3782886) was shown to be associated with high platelet count and short stature. This result partly explains how a genetic factor can influence the impact of height on endothelial repair.

Citing Articles

Progression of Carotid Intima-Media Thickness Partly Indicates the Prevention of Hypertension among Older Individuals in the General Population.

Shimizu Y Life (Basel). 2023; 13(7).

PMID: 37511963 PMC: 10381883. DOI: 10.3390/life13071588.

Analysis of risk factors and construction of a prediction model for short stature in children.

Huang S, Chen Z, Chen R, Zhang Z, Sun J, Chen H Front Pediatr. 2022; 10:1006011.

PMID: 36561487 PMC: 9763591. DOI: 10.3389/fped.2022.1006011.

Height and Active Arterial Wall Thickening in Relation to Thyroid Cysts Status among Elderly Japanese: A Prospective Study.

Shimizu Y, Kawashiri S, Noguchi Y, Nakamichi S, Nagata Y, Maeda T Biology (Basel). 2022; 11(12).

PMID: 36552266 PMC: 9775353. DOI: 10.3390/biology11121756.

Influence of height on endothelial maintenance activity: a narrative review.

Shimizu Y, Maeda T Environ Health Prev Med. 2021; 26(1):19.

PMID: 33549053 PMC: 7866474. DOI: 10.1186/s12199-021-00941-5.

Contribution of VEGF polymorphism rs3025020 to short stature and hypertension in elderly Japanese individuals: a cross-sectional study.

Shimizu Y, Yamanashi H, Kawashiri S, Nobusue K, Nonaka F, Noguchi Y J Physiol Anthropol. 2021; 40(1):4.

PMID: 33541438 PMC: 7863239. DOI: 10.1186/s40101-021-00253-1.

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