How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2019 May 1

PMID 31035321

Citations 36

Authors

Patrice Forget

Jose A Aguirre

Ivanka Bencic

Alain Borgeat

Allessandro Cama

Claire Condron

Christina Eintrei

Pilar Eroles

Anil Gupta

Tim G Hales

Daniela Ionescu

Mark Johnson

Pawel Kabata

Iva Kirac

Daqing Ma

Zhirajr Mokini

Jose Luis Guerrero Orriach

Michael Retsky

Sergio Sandrucci

Wiebke Siekmann

Ljilja Stefancic

Gina Votta-Vellis

Cara Connolly

Donal Buggy

Affiliations

Soon will be listed here.

Abstract

The question of whether anesthetic, analgesic or other perioperative intervention during cancer resection surgery might influence long-term oncologic outcomes has generated much attention over the past 13 years. A wealth of experimental and observational clinical data have been published, but the results of prospective, randomized clinical trials are awaited. The European Union supports a pan-European network of researchers, clinicians and industry partners engaged in this question (COST Action 15204: Euro-Periscope). In this narrative review, members of the Euro-Periscope network briefly summarize the current state of evidence pertaining to the potential effects of the most commonly deployed anesthetic and analgesic techniques and other non-surgical interventions during cancer resection surgery on tumor recurrence or metastasis.

Citing Articles

Study on the effects of intraoperative administration of dexmedetomidine on the prognosis and survival outcomes of patients with colorectal cancer.

Ren C, Zeng Y, Qiu L, Luo D, Wang J, Chen X Heliyon. 2024; 10(19):e38241.

PMID: 39381090 PMC: 11456851. DOI: 10.1016/j.heliyon.2024.e38241.

Comparing postoperative pain relief: ketorolac and Nasocalcin spray versus lidocaine and Nasocalcin spray in abdominal surgery patients.

Fakhr M, Qasemi M, Rezvanfar K, Hosseini R, Amini Z, Amiri K Ann Med Surg (Lond). 2024; 86(10):5823-5829.

PMID: 39359836 PMC: 11444628. DOI: 10.1097/MS9.0000000000002285.

Pain Management in Animals with Oncological Disease: Opioids as Influencers of Immune and Tumor Cellular Balance.

Pinheiro A, Petrucci G, Dourado A, Silva F, Pires I Cancers (Basel). 2024; 16(17).

PMID: 39272873 PMC: 11394036. DOI: 10.3390/cancers16173015.

Anesthesia and cancer recurrence: a narrative review.

Ahn H Anesth Pain Med (Seoul). 2024; 19(2):94-108.

PMID: 38725164 PMC: 11089301. DOI: 10.17085/apm.24041.

Lidocaine Inhibits Rat Prostate Cancer Cell Invasiveness and Voltage-Gated Sodium Channel Expression in Plasma Membrane.

Rizaner N, Fraser S, Gul I, Purut E, Djamgoz M, Altun S J Membr Biol. 2024; 257(1-2):17-24.

PMID: 38165418 DOI: 10.1007/s00232-023-00302-z.

References

Senkal M, Zumtobel V, Bauer K, Marpe B, Wolfram G, Frei A . Outcome and cost-effectiveness of perioperative enteral immunonutrition in patients undergoing elective upper gastrointestinal tract surgery: a prospective randomized study. Arch Surg. 1999; 134(12):1309-16. DOI: 10.1001/archsurg.134.12.1309. View

Heyland D, Novak F, Drover J, Jain M, Su X, Suchner U . Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA. 2001; 286(8):944-53. DOI: 10.1001/jama.286.8.944. View

Braga M, Gianotti L, Nespoli L, Radaelli G, Di Carlo V . Nutritional approach in malnourished surgical patients: a prospective randomized study. Arch Surg. 2002; 137(2):174-80. DOI: 10.1001/archsurg.137.2.174. View

Topp R, Ditmyer M, King K, Doherty K, Hornyak 3rd J . The effect of bed rest and potential of prehabilitation on patients in the intensive care unit. AACN Clin Issues. 2002; 13(2):263-76. DOI: 10.1097/00044067-200205000-00011. View

Gianotti L, Braga M, Nespoli L, Radaelli G, Beneduce A, Di Carlo V . A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer. Gastroenterology. 2002; 122(7):1763-70. DOI: 10.1053/gast.2002.33587. View

Gupta K, Kshirsagar S, Chang L, Schwartz R, Law P, Yee D . Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Res. 2002; 62(15):4491-8. View

Ditmyer M, Topp R, Pifer M . Prehabilitation in preparation for orthopaedic surgery. Orthop Nurs. 2002; 21(5):43-51; quiz 52-4. DOI: 10.1097/00006416-200209000-00008. View

Kondrup J, Allison S, Elia M, Vellas B, Plauth M . ESPEN guidelines for nutrition screening 2002. Clin Nutr. 2003; 22(4):415-21. DOI: 10.1016/s0261-5614(03)00098-0. View

Pawitan Y, Michiels S, Koscielny S, Gusnanto A, Ploner A . False discovery rate, sensitivity and sample size for microarray studies. Bioinformatics. 2005; 21(13):3017-24. DOI: 10.1093/bioinformatics/bti448. View

10.

Klek S, Kulig J, Szczepanik A, Jedrys J, Kolodziejczyk P . The clinical value of parenteral immunonutrition in surgical patients. Acta Chir Belg. 2005; 105(2):175-9. View

11.

Sakaguchi M, Kuroda Y, Hirose M . The antiproliferative effect of lidocaine on human tongue cancer cells with inhibition of the activity of epidermal growth factor receptor. Anesth Analg. 2006; 102(4):1103-7. DOI: 10.1213/01.ane.0000198330.84341.35. View

12.

Lobo D, Williams R, Welch N, Aloysius M, Nunes Q, Padmanabhan J . Early postoperative jejunostomy feeding with an immune modulating diet in patients undergoing resectional surgery for upper gastrointestinal cancer: a prospective, randomized, controlled, double-blind study. Clin Nutr. 2006; 25(5):716-26. DOI: 10.1016/j.clnu.2006.04.007. View

13.

Waitzberg D, Saito H, Plank L, Jamieson G, Jagannath P, Hwang T . Postsurgical infections are reduced with specialized nutrition support. World J Surg. 2006; 30(8):1592-604. DOI: 10.1007/s00268-005-0657-x. View

14.

Xu J, Zhong Y, Jing D, Wu Z . Preoperative enteral immunonutrition improves postoperative outcome in patients with gastrointestinal cancer. World J Surg. 2006; 30(7):1284-9. DOI: 10.1007/s00268-005-0756-8. View

15.

Gianotti L . Nutrition and infections. Surg Infect (Larchmt). 2006; 7 Suppl 2:S29-32. DOI: 10.1089/sur.2006.7.s2-29. View

16.

Horie H, Okada M, Kojima M, Nagai H . Favorable effects of preoperative enteral immunonutrition on a surgical site infection in patients with colorectal cancer without malnutrition. Surg Today. 2006; 36(12):1063-8. DOI: 10.1007/s00595-006-3320-8. View

17.

Zheng Y, Li F, Qi B, Luo B, Sun H, Liu S . Application of perioperative immunonutrition for gastrointestinal surgery: a meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr. 2007; 16 Suppl 1:253-7. View

18.

Giger U, Buchler M, Farhadi J, Berger D, Husler J, Schneider H . Preoperative immunonutrition suppresses perioperative inflammatory response in patients with major abdominal surgery-a randomized controlled pilot study. Ann Surg Oncol. 2007; 14(10):2798-806. DOI: 10.1245/s10434-007-9407-7. View

19.

Bozzetti F, Gianotti L, Braga M, Di Carlo V, Mariani L . Postoperative complications in gastrointestinal cancer patients: the joint role of the nutritional status and the nutritional support. Clin Nutr. 2007; 26(6):698-709. DOI: 10.1016/j.clnu.2007.06.009. View

20.

Takeuchi H, Ikeuchi S, Kawaguchi Y, Kitagawa Y, Isobe Y, Kubochi K . Clinical significance of perioperative immunonutrition for patients with esophageal cancer. World J Surg. 2007; 31(11):2160-7. DOI: 10.1007/s00268-007-9219-8. View