Wnt Signaling: A Potential Therapeutic Target in Head And Neck Squamous Cell Carcinoma

Overview

Journal Asian Pac J Cancer Prev

Specialty Oncology

Date 2019 Apr 29

PMID 31030466

Citations 14

Authors

Zeeshan Javed

Hafiz Muhammad Farooq

Mukhtar Ullah

Muhammad Zaheer Iqbal

Qamar Raza

Haleema Sadia

Raffaele Pezzani

Bahare Salehi

Javad Sharifi-Rad

William C Cho

Affiliations

Soon will be listed here.

Abstract

Cellular maintenance and development are two fundamental mechanisms regulated by the canonical Wnt signaling pathway. Wnt/beta-catenin signaling pathway controls a myriad of cellular processes that are essential for normal cell functioning. Cell cycle progression, differentiation, fate determination, and migration are generally orchestrated by canonical Wnt signaling. Altered Wnt/beta-catenin signaling has been considered a promoting event for different types of cancers and the oncogenic potential of Wnt signaling have been discussed in many cancer types, including breast, colon, pancreatic as well as head and neck. Furthermore, Wnt signaling is critical for the maintenance and stemness of both the normal as well as cancer stem cells. This review sheds new light on Wnt signaling and explains how it can regulate normal physiological processes and curtail the development of cancer. It depicts the vital functions of Wnt signaling in the stem cell growth and differentiation by focusing on current druggable targets that have been ascribed by recent studies. Thus, Wnt signaling pathway retains a tremendous potential in eradicating head and neck squamous cell carcinoma.

Citing Articles

Tumor histoculture captures the dynamic interactions between tumor and immune components in response to anti-PD1 in head and neck cancer.

Basak N, Jaganathan K, Das B, Muthusamy O, M R, Malhotra R Nat Commun. 2024; 15(1):1585.

PMID: 38383563 PMC: 10881470. DOI: 10.1038/s41467-024-45723-z.

Combinations of PRI-724 Wnt/β-Catenin Pathway Inhibitor with Vismodegib, Erlotinib, or HS-173 Synergistically Inhibit Head and Neck Squamous Cancer Cells.

Kleszcz R, Frackowiak M, Dorna D, Paluszczak J Int J Mol Sci. 2023; 24(13).

PMID: 37445628 PMC: 10341739. DOI: 10.3390/ijms241310448.

Pancreatic cancer stemness: dynamic status in malignant progression.

Zhao Y, Qin C, Zhao B, Wang Y, Li Z, Li T J Exp Clin Cancer Res. 2023; 42(1):122.

PMID: 37173787 PMC: 10182699. DOI: 10.1186/s13046-023-02693-2.

PLODs: Novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinoma.

Gong S, Wu C, Duan Y, Fu J, Wang Y, Wu H Heliyon. 2023; 9(2):e13479.

PMID: 36820030 PMC: 9937984. DOI: 10.1016/j.heliyon.2023.e13479.

CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma.

Shen Y, Chen Y, Lin Y, Li Y, Liu P, Zhang B Cell Death Dis. 2023; 14(2):107.

PMID: 36774351 PMC: 9922250. DOI: 10.1038/s41419-023-05652-z.

References

Gao Z, Xu Z, Hung M, Lin Y, Wang T, Gong M . Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells. Anticancer Res. 2009; 29(6):2025-30. View

MacDonald B, Tamai K, He X . Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell. 2009; 17(1):9-26. PMC: 2861485. DOI: 10.1016/j.devcel.2009.06.016. View

Roettger A, Bruchhage K, Drenckhan M, Ploetze-Martin K, Pries R, Wollenberg B . Inhibitory Effect of 1,8-Cineol on β-Catenin Regulation, WNT11 Expression, and Cellular Progression in HNSCC. Front Oncol. 2017; 7:92. PMC: 5438970. DOI: 10.3389/fonc.2017.00092. View

Proffitt K, Madan B, Ke Z, Pendharkar V, Ding L, Lee M . Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2012; 73(2):502-7. DOI: 10.1158/0008-5472.CAN-12-2258. View

Leethanakul C, Patel V, Gillespie J, Pallente M, Ensley J, Koontongkaew S . Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene. 2000; 19(28):3220-4. DOI: 10.1038/sj.onc.1203703. View

Song J, Chang I, Chen Z, Kang M, Wang C . Characterization of side populations in HNSCC: highly invasive, chemoresistant and abnormal Wnt signaling. PLoS One. 2010; 5(7):e11456. PMC: 2897893. DOI: 10.1371/journal.pone.0011456. View

Cojoc M, Mabert K, Muders M, Dubrovska A . A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms. Semin Cancer Biol. 2014; 31:16-27. DOI: 10.1016/j.semcancer.2014.06.004. View

Padhi S, Saha A, Kar M, Ghosh C, Adhya A, Baisakh M . Clinico-Pathological Correlation of β-Catenin and Telomere Dysfunction in Head and Neck Squamous Cell Carcinoma Patients. J Cancer. 2015; 6(2):192-202. PMC: 4314668. DOI: 10.7150/jca.9558. View

Kabiri Z, Numata A, Kawasaki A, Edison , Tenen D, Virshup D . Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells. Blood. 2015; 126(9):1086-94. PMC: 4598194. DOI: 10.1182/blood-2014-09-598540. View

10.

Bray F, Ren J, Masuyer E, Ferlay J . Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2012; 132(5):1133-45. DOI: 10.1002/ijc.27711. View

11.

Ozbey U, Attar R, Romero M, Alhewairini S, Afshar B, Sabitaliyevich U . Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/β-catenin, JAK-STAT pathways, and microRNAs. J Cell Biochem. 2018; 120(2):1060-1067. DOI: 10.1002/jcb.27575. View

12.

Nwanze J, Cohen C, Schmitt A, Siddiqui M . β-Catenin Expression in Oropharyngeal Squamous Cell Carcinomas: Comparison and Correlation with p16 and Human Papillomavirus in situ Hybridization. Acta Cytol. 2016; 59(6):479-84. DOI: 10.1159/000443602. View

13.

Beck T, Golemis E . Genomic insights into head and neck cancer. Cancers Head Neck. 2017; 1. PMC: 5638139. DOI: 10.1186/s41199-016-0003-z. View

14.

Schepers U . A stem cell molecular signature: are there hallmark properties that are shared by all stem cells?. Chembiochem. 2003; 4(8):716-20. DOI: 10.1002/cbic.200300661. View

15.

Chikazawa N, Tanaka H, Tasaka T, Nakamura M, Tanaka M, Onishi H . Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells. Anticancer Res. 2010; 30(6):2041-8. View

16.

Aminuddin A, Ng P . Promising Druggable Target in Head and Neck Squamous Cell Carcinoma: Wnt Signaling. Front Pharmacol. 2016; 7:244. PMC: 4982242. DOI: 10.3389/fphar.2016.00244. View

17.

Modur V, Joshi P, Nie D, Robbins K, Khan A, Rao K . CD24 Expression May Play a Role as a Predictive Indicator and a Modulator of Cisplatin Treatment Response in Head and Neck Squamous Cellular Carcinoma. PLoS One. 2016; 11(6):e0156651. PMC: 4898769. DOI: 10.1371/journal.pone.0156651. View

18.

Yanamoto S, Yamada S, Takahashi H, Naruse T, Matsushita Y, Ikeda H . Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: effect of neoadjuvant chemotherapy on local recurrence. Int J Oncol. 2014; 44(4):1153-62. DOI: 10.3892/ijo.2014.2289. View

19.

Peerani R, Rao B, Bauwens C, Yin T, Wood G, Nagy A . Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J. 2007; 26(22):4744-55. PMC: 2080799. DOI: 10.1038/sj.emboj.7601896. View

20.

Yao C, Lai G, Yeh C, Lai M, Shih P, Chao W . Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/ β -Catenin Signaling and Apoptosis Induction. Evid Based Complement Alternat Med. 2013; 2013:146136. PMC: 3638590. DOI: 10.1155/2013/146136. View