Plasma -synuclein Levels Are Increased in Patients with Obstructive Sleep Apnea Syndrome

Overview

Journal Ann Clin Transl Neurol

Specialty Neurology

Date 2019 Apr 26

PMID 31020003

Citations 16

Authors

Hao-Lun Sun

Bin-Lu Sun

Dong-Wan Chen

Yang Chen

Wei-Wei Li

Man-Yu Xu

Ying-Ying Shen

Zhi-Qiang Xu

Yan-Jiang Wang

Xian-Le Bu

Affiliations

Soon will be listed here.

Abstract

Objective: Obstructive sleep apnea syndrome (OSAS) is characterized by nocturnal intermittent hypoxemia and can increase the risk of Parkinson's disease. This study aimed to investigate the association between plasma -synuclein levels and hypoxia in the patients with OSAS.

Methods: We recruited 42 OSAS patients and 46 controls with simple snoring matched for age and gender. OSAS was diagnosed on the basis of the clinical symptoms as well as the nighttime polysomnography. Plasma total -synuclein and phosphorylated -synuclein levels were measured by ELISA kits.

Results: The OSAS patients had significant higher levels of plasma total -synuclein and phosphorylated -synuclein levels. Both of the above indexes were positively correlated with the apnea-hypopnea index and the oxygen desaturation index, while they were negatively correlated with the mean and lowest oxyhemoglobin saturations.

Interpretation: This study suggests that chronic intermittent hypoxia can increase the -synuclein levels, which may contribute to the pathogenesis of Parkinson's disease.

Citing Articles

Hypoxia Pathways in Parkinson's Disease: From Pathogenesis to Therapeutic Targets.

Gao Y, Zhang J, Tang T, Liu Z Int J Mol Sci. 2024; 25(19).

PMID: 39408813 PMC: 11477385. DOI: 10.3390/ijms251910484.

Spiral volumetric optoacoustic tomography of reduced oxygen saturation in the spinal cord of M83 mouse model of Parkinson's disease.

Combes B, Kalva S, Benveniste P, Tournant A, Law M, Newton J Eur J Nucl Med Mol Imaging. 2024; 52(2):427-443.

PMID: 39382580 PMC: 11732882. DOI: 10.1007/s00259-024-06938-w.

A diagnostic model for Parkinson's disease based on circadian rhythm-related genes.

Wang L, Bao Y, Duan X, Li H, Ding H, Yu F J Transl Med. 2024; 22(1):635.

PMID: 38978048 PMC: 11229228. DOI: 10.1186/s12967-024-05424-z.

The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration.

Mitroshina E, Vedunova M Int J Mol Sci. 2024; 25(9).

PMID: 38731800 PMC: 11083463. DOI: 10.3390/ijms25094581.

Cerebral perfusion is not impaired in persons with moderate obstructive sleep apnoea when awake.

Buckley R, Innes C, Kelly P, Hlavac M, Beckert L, Melzer T Sleep Breath. 2024; 28(4):1609-1616.

PMID: 38717716 DOI: 10.1007/s11325-024-03048-7.

References

Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee V . Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions. J Biol Chem. 2002; 277(50):49071-6. DOI: 10.1074/jbc.M208046200. View

Qureshi A, Ballard R . Obstructive sleep apnea. J Allergy Clin Immunol. 2003; 112(4):643-51. DOI: 10.1016/j.jaci.2003.08.031. View

Ltic S, Perovic M, Mladenovic A, Raicevic N, Ruzdijic S, Rakic L . Alpha-synuclein is expressed in different tissues during human fetal development. J Mol Neurosci. 2004; 22(3):199-204. DOI: 10.1385/jmn:22:3:199. View

Hu X, Rea H, Wiktorowicz J, Perez-Polo J . Proteomic analysis of hypoxia/ischemia-induced alteration of cortical development and dopamine neurotransmission in neonatal rat. J Proteome Res. 2006; 5(9):2396-404. PMC: 3128998. DOI: 10.1021/pr060209x. View

Barbour R, Kling K, Anderson J, Banducci K, Cole T, Diep L . Red blood cells are the major source of alpha-synuclein in blood. Neurodegener Dis. 2008; 5(2):55-9. DOI: 10.1159/000112832. View

Norlinah M, Afidah K, Noradina A, Shamsul A, Hamidon B, Sahathevan R . Sleep disturbances in Malaysian patients with Parkinson's disease using polysomnography and PDSS. Parkinsonism Relat Disord. 2009; 15(9):670-4. DOI: 10.1016/j.parkreldis.2009.02.012. View

Zoccolella S, Savarese M, Lamberti P, Manni R, Pacchetti C, Logroscino G . Sleep disorders and the natural history of Parkinson's disease: the contribution of epidemiological studies. Sleep Med Rev. 2010; 15(1):41-50. DOI: 10.1016/j.smrv.2010.02.004. View

Huang J, Zhang J, Lam S, Li S, Ho C, Lam V . Amelioration of obstructive sleep apnea in REM sleep behavior disorder: implications for the neuromuscular control of OSA. Sleep. 2011; 34(7):909-15. PMC: 3119833. DOI: 10.5665/SLEEP.1126. View

Foulds P, Mitchell J, Parker A, Turner R, Green G, Diggle P . Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease. FASEB J. 2011; 25(12):4127-37. DOI: 10.1096/fj.10-179192. View

10.

Thornton A, Singh P, Ruehland W, Rochford P . AASM criteria for scoring respiratory events: interaction between apnea sensor and hypopnea definition. Sleep. 2012; 35(3):425-32. PMC: 3274344. DOI: 10.5665/sleep.1710. View

11.

Sokucu S, Karasulu L, Dalar L, Seyhan E, Altin S . Can red blood cell distribution width predict severity of obstructive sleep apnea syndrome?. J Clin Sleep Med. 2012; 8(5):521-5. PMC: 3459197. DOI: 10.5664/jcsm.2146. View

12.

Berry R, Budhiraja R, Gottlieb D, Gozal D, Iber C, Kapur V . Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med. 2012; 8(5):597-619. PMC: 3459210. DOI: 10.5664/jcsm.2172. View

13.

Foulds P, Diggle P, Mitchell J, Parker A, Hasegawa M, Masuda-Suzukake M . A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease. Sci Rep. 2013; 3:2540. PMC: 3756331. DOI: 10.1038/srep02540. View

14.

Pukass K, Richter-Landsberg C . Oxidative stress promotes uptake, accumulation, and oligomerization of extracellular α-synuclein in oligodendrocytes. J Mol Neurosci. 2013; 52(3):339-52. DOI: 10.1007/s12031-013-0154-x. View

15.

Chen T, Li J, Chao D, Sandhu H, Liao X, Zhao J . δ-Opioid receptor activation reduces α-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia. Exp Neurol. 2014; 255:127-36. DOI: 10.1016/j.expneurol.2014.02.022. View

16.

Andreou G, Vlachos F, Makanikas K . Effects of chronic obstructive pulmonary disease and obstructive sleep apnea on cognitive functions: evidence for a common nature. Sleep Disord. 2014; 2014:768210. PMC: 3932644. DOI: 10.1155/2014/768210. View

17.

Malek N, Swallow D, Grosset K, Anichtchik O, Spillantini M, Grosset D . Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review. Acta Neurol Scand. 2014; 130(2):59-72. DOI: 10.1111/ane.12247. View

18.

Sacino A, Brooks M, Thomas M, McKinney A, Lee S, Regenhardt R . Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc Natl Acad Sci U S A. 2014; 111(29):10732-7. PMC: 4115570. DOI: 10.1073/pnas.1321785111. View

19.

Chen J, Tsai T, Li C, Hwang J . Obstructive sleep apnea and risk of Parkinson's disease: a population-based cohort study. J Sleep Res. 2015; 24(4):432-7. DOI: 10.1111/jsr.12289. View

20.

Burre J, Sharma M, Sudhof T . Definition of a molecular pathway mediating α-synuclein neurotoxicity. J Neurosci. 2015; 35(13):5221-32. PMC: 4380997. DOI: 10.1523/JNEUROSCI.4650-14.2015. View