Non-secretion of ABO Blood Group Antigens As a Host Susceptibility Factor in the Spondyloarthropathies

Overview

Journal Br Med J (Clin Res Ed)

Specialty General Medicine

Date 1987 Jan 24

PMID 3101813

Citations 11

Authors

R Shinebaum

C C Blackwell

P J Forster

N P Hurst

D M WEIR

G Nuki

Affiliations

Soon will be listed here.

Abstract

Gram negative bacteria precipitate reactive arthritis and may be concerned in the pathogenesis of ankylosing spondylitis and other spondyloarthropathies. Susceptibility to many infectious agents is associated with ABO blood group or secretor state, or both. The distribution of the ABO blood group or secretor state, or both, was therefore determined in 87 patients with ankylosing spondylitis and 32 with other forms of spondyloarthropathy. The prevalence of non-secretors was significantly increased in the total patient group (54/114; 47%) and in the subgroup with ankylosing spondylitis (41/84; 49%) compared with local controls (89/334; 27%) (p less than 0.001). Other subgroups of patients showed a similarly increased prevalence of non-secretion (33-47%). The distribution of ABO blood groups did not differ between patients and controls. The association between non-secretor state and ankylosing spondylitis strengthens the hypothesis that ankylosing spondylitis is a form of reactive arthritis. It also suggests several pathogenic mechanisms which may be relevant to the initial hostparasite interaction in ankylosing spondylitis.

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References

Veys E, van Leare M . Serum IgG, IgM, and IgA levels in ankylosing spondylitis. Ann Rheum Dis. 1973; 32(6):493-6. PMC: 1006157. DOI: 10.1136/ard.32.6.493. View

Eastmond C, Willshaw H, Burgess S, Shinebaum R, Cooke E, WRIGHT V . Frequency of faecal Klebsiella aerogenes in patients with ankylosing spondylitis and controls with respect to individual features of the disease. Ann Rheum Dis. 1980; 39(2):118-23. PMC: 1000493. DOI: 10.1136/ard.39.2.118. View

Ebringer R, Cooke D, Cawdell D, Cowling P, Ebringer A . Ankylosing spondylitis: klebsiella and HL-A B27. Rheumatol Rehabil. 1977; 16(3):190-6. DOI: 10.1093/rheumatology/16.3.190. View

BREWERTON D . Joseph J. Bunim Memorial Lecture. HLA-B27 and the inheritance of susceptibility to rheumatic disease. Arthritis Rheum. 1976; 19(4):656-68. DOI: 10.1002/1529-0131(197607/08)19:4<656::aid-art1780190402>3.0.co;2-n. View

Willkens R, Arnett F, Bitter T, Calin A, Fisher L, FORD D . Reiter's syndrome. Evaluation of preliminary criteria for definite disease. Arthritis Rheum. 1981; 24(6):844-9. DOI: 10.1002/art.1780240612. View

Lomberg H, Cedergren B, Leffler H, Nilsson B, Carlstrom A . Influence of blood group on the availability of receptors for attachment of uropathogenic Escherichia coli. Infect Immun. 1986; 51(3):919-26. PMC: 260986. DOI: 10.1128/iai.51.3.919-926.1986. View

MILLER L, Mason S, DVORAK J, McGinniss M, Rothman I . Erythrocyte receptors for (Plasmodium knowlesi) malaria: Duffy blood group determinants. Science. 1975; 189(4202):561-3. DOI: 10.1126/science.1145213. View

Warren R, BREWERTON D . Faecal carriage of klebsiella by patients with ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis. 1980; 39(1):37-44. PMC: 1000467. DOI: 10.1136/ard.39.1.37. View

Blackwell C, Jonsdottir K, Hanson M, Todd W, Chaudhuri A, Mathew B . Non-secretion of ABO antigens predisposing to infection by Neisseria meningitidis and Streptococcus pneumoniae. Lancet. 1986; 2(8501):284-5. DOI: 10.1016/s0140-6736(86)92103-3. View

10.

Hind C . Reactive arthritis. Postgrad Med J. 1982; 58(677):131-7. PMC: 2426363. DOI: 10.1136/pgmj.58.677.131. View

11.

Grundbacher F . Immunoglobulins, secretor status, and the incidence of rheumatic fever and rheumatic heart disease. Hum Hered. 1972; 22(4):399-404. DOI: 10.1159/000152516. View

12.

Beaulieu A, Rousseau F, Israel-Assayag E, Roy R . Klebsiella related antigens in ankylosing spondylitis. J Rheumatol. 1983; 10(1):102-5. View

13.

Waissbluth J, Langman M . ABO blood groups, secretor status, salivary protein, and serum and salivary immunoglobulin concentrations. Gut. 1971; 12(8):646-9. PMC: 1411748. DOI: 10.1136/gut.12.8.646. View

14.

Kumazaki T, Yoshida A . Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase. Proc Natl Acad Sci U S A. 1984; 81(13):4193-7. PMC: 345395. DOI: 10.1073/pnas.81.13.4193. View

15.

Barua D, Paguio A . ABO blood groups and cholera. Ann Hum Biol. 1977; 4(5):489-92. DOI: 10.1080/03014467700002481. View

16.

Chaudhuri A, DASADHIKARY C . Possible role of blood-group secretory substances in the aetiology of cholera. Trans R Soc Trop Med Hyg. 1978; 72(6):664-5. DOI: 10.1016/0035-9203(78)90031-7. View

17.

Olhagen B . Postinfective or reactive arthritis. Scand J Rheumatol. 1980; 9(4):193-202. DOI: 10.3109/03009748009112346. View

18.

Robinson M, Tolchin D, Halpern C . Enteric bacterial agents and the ABO blood groups. Am J Hum Genet. 1971; 23(2):135-45. PMC: 1706692. View

19.

Neumann V, WRIGHT V . Arthritis associated with bowel disease. Clin Gastroenterol. 1983; 12(3):767-95. View

20.

Kinane D, Blackwell C, Winstanley F, WEIR D . Blood group, secretor status, and susceptibility to infection by Neisseria gonorrhoeae. Br J Vener Dis. 1983; 59(1):44-6. PMC: 1046129. DOI: 10.1136/sti.59.1.44. View