A Kinetic Study of the Melanization Pathway Between L-tyrosine and Dopachrome

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 1987 Feb 20

PMID 3101741

Citations 25

Authors

J Cabanes

F Garcia-Canovas

J A Lozano

F Garcia-Carmona

Affiliations

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Abstract

In the pathway of melanin biosynthesis originating from L-tyrosine, the dopachrome accumulation at physiological pH is produced with a pronounced lag period, during which the level of L-dopa increases, following a sigmoidal kinetics to reach a steady-state. A kinetic model has been proposed for the overall pathway of melanization from L-tyrosine to dopachrome; it explains the lag period present during the dopachrome accumulation as well as the influence of L-tyrosine and tyrosinase over this lag period. Use of this model is also valid to explain the kinetics of L-dopa accumulation in the reaction medium, as has been tested by simulation.

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