Relationship Between the Shift of the Retinal Artery Associated With Myopia and Ocular Response Analyzer Waveform Parameters

Overview

Journal Transl Vis Sci Technol

Specialties Biomedical Engineering
Ophthalmology

Date 2019 Apr 25

PMID 31016069

Citations 5

Authors

Shotaro Asano

Ryo Asaoka

Takehiro Yamashita

Shuichiro Aoki

Masato Matsuura

Yuri Fujino

Hiroshi Murata

Shunsuke Nakakura

Yoshitaka Nakao

Yoshiaki Kiuchi

Affiliations

Soon will be listed here.

Abstract

Purpose: We have recently reported that the retinal stretch due to myopia is closely related to the peripapillary retinal arteries angle (PRAA) (Yamashita et al., 2013;54:5481-5488). The purpose of the current study was to investigate the relationship between retinal artery position and Ocular Response Analyzer (ORA) waveform parameters.

Methods: In 43 eyes of 41 healthy subjects, ORA measurements were carried out and the PRAA was calculated from fundus photographs. Then, the variables related to PRAA were identified from 40 variables of age, axial length (AL), keratometry, ORA corneal hysteresis (CH), ORA corneal resistant factor (CRF), and 35 ORA waveform parameters, using the Lasso regression and model selection with the second-order bias-corrected Akaike information criterion index.

Results: The optimal model for PRAA included AL, CRF, and three ORA waveform parameters (aindex, w2, and slew1). This optimal model was significantly better than the model with AL-only, the model only with AL and CH, and the model only with AL and CRF ( < 0.0001, < 0.0001, < 0.0001, respectively; analysis of variance).

Conclusions: The PRAA was significantly better represented by using AL and ORA parameters including waveform parameters, compared with AL alone, with AL and CH alone, and with AL and CRF alone.

Translational Relevance: ORA waveform, which represents corneal biomechanical properties, was associated with myopic retinal stretch.

Citing Articles

Advanced ultrawide-field optical coherence tomography angiography identifies previously undetectable changes in biomechanics-related parameters in nonpathological myopic fundus.

Zhang W, Li C, Gong Y, Liu N, Cao Y, Li Z Front Bioeng Biotechnol. 2022; 10:920197.

PMID: 36051579 PMC: 9424555. DOI: 10.3389/fbioe.2022.920197.

Retinal vessel shift and its association with axial length elongation in a prospective observation in Japanese junior high school students.

Asano S, Yamashita T, Asaoka R, Fujino Y, Murata H, Terasaki H PLoS One. 2021; 16(4):e0250233.

PMID: 33886637 PMC: 8062002. DOI: 10.1371/journal.pone.0250233.

Relationship Between Macular Ganglion Cell Thickness and Ocular Elongation as Measured by Axial Length and Retinal Artery Position.

Omoto T, Murata H, Fujino Y, Matsuura M, Fujishiro T, Hirasawa K Invest Ophthalmol Vis Sci. 2020; 61(11):16.

PMID: 32915981 PMC: 7488627. DOI: 10.1167/iovs.61.11.16.

Visualizing the dynamic change of Ocular Response Analyzer waveform using Variational Autoencoder in association with the peripapillary retinal arteries angle.

Asano S, Asaoka R, Yamashita T, Aoki S, Matsuura M, Fujino Y Sci Rep. 2020; 10(1):6592.

PMID: 32313133 PMC: 7170838. DOI: 10.1038/s41598-020-63601-8.

Correlation Between the Myopic Retinal Deformation and Corneal Biomechanical Characteristics Measured With the Corvis ST Tonometry.

Asano S, Asaoka R, Yamashita T, Aoki S, Matsuura M, Fujino Y Transl Vis Sci Technol. 2019; 8(4):26.

PMID: 31440423 PMC: 6701875. DOI: 10.1167/tvst.8.4.26.

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