Long-Term Natural Course of Pathologic Myopia in Chinese Patients

Overview

Journal J Ophthalmol

Publisher Wiley

Specialty Ophthalmology

Date 2019 Apr 25

PMID 31016036

Citations 4

Authors

Minjie Chen

Manrong Yu

Jinhui Dai

Renyuan Chu

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate the natural progression in Chinese patients with pathological myopia (PM) and its associated factors.

Methods: The medical records of 28 patients with PM (worse than -6 diopter), including 31 eyes of 21 children and 12 eyes of 7 adults, were studied. All of the patients underwent a complete ophthalmologic examination at least twice over 3-year period, including the measurement of refractive error (shown as spherical equivalent, SE), axial length (AL), intraocular pressure, visual acuity (uncorrected visual acuity, UCVA, and best-corrected visual acuity, BCVA), and dilated fundus examination.

Results: The median AL of adults increased significantly from 29.8 mm to 31.43 mm over 5.4 years follow-up (=0.0037), accompanied with the median SE progressing significantly from -16.4 D to -18.94 D (=0.0005). Similarly, the median AL of children increased significantly from 26.13 mm to 27.81 mm over 3.9 years (=0.0001). However, the improvements of UCVA and BCVA in children were significant (=0.0304, 0.0001), and they had a negative correlation with age (=0.0010, 0.0005). Also, UCVA and BCVA in children with bilateral PM were significantly better than those with unilateral PM (=0.0385, 0.0210).

Conclusions: Fundus degenerations in children with pathological myopia may lead its way since the age of 10 years. Besides, children with bilateral pathological myopia can have parallel development in visual acuity.

Citing Articles

Longitudinal Changes in Axial Length and Spherical Equivalent in Children and Adolescents With High Myopia.

Jiang F, Wang D, Yin Q, He M, Li Z Invest Ophthalmol Vis Sci. 2023; 64(12):6.

PMID: 37669064 PMC: 10484013. DOI: 10.1167/iovs.64.12.6.

Association Between the Types of Posterior Staphyloma and Their Risk Factors in Pathological Myopia.

An G, Dai F, Wang R, Liu Z, Guo J, Pan M Transl Vis Sci Technol. 2021; 10(4):5.

PMID: 34003983 PMC: 8039568. DOI: 10.1167/tvst.10.4.5.

PI3K/AKT/mTOR signaling participates in insulin-mediated regulation of pathological myopia-related factors in retinal pigment epithelial cells.

Li Y, Jiang J, Yang J, Xiao L, Hua Q, Zou Y BMC Ophthalmol. 2021; 21(1):218.

PMID: 34001063 PMC: 8127189. DOI: 10.1186/s12886-021-01946-y.

Long-term longitudinal changes in axial length in the Caucasian myopic and hyperopic population with a phakic intraocular lens.

Gaurisankar Z, van Rijn G, Haasnoot G, Verhoeven V, Klaver C, Luyten G Acta Ophthalmol. 2020; 99(4):e562-e568.

PMID: 33124166 PMC: 8359445. DOI: 10.1111/aos.14647.

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