Innate Immune Protein Tag7 Stimulates the Appearance of Cytotoxic NK Cells After Incubation with Lymphocytes

Overview

Journal Dokl Biochem Biophys

Specialties Biochemistry
Biophysics

Date 2019 Apr 24

PMID 31012024

Citations 1

Authors

T N Sharapova

E A Romanova

L P Sashchenko

N V Gnuchev

D V Yashin

Affiliations

Soon will be listed here.

Abstract

Tag7 (PGRP-S) is an innate immune protein that is involved in the antibacterial and antitumor defense and stimulates the maturation of cytotoxic lymphocyte subpopulations. It was found that the incubation of lymphocytes with Tag7 for 3 days promotes the appearance of cytotoxic NK cells that are active against a number of tumor cell lines.

Citing Articles

Hsp70 Interacts with the TREM-1 Receptor Expressed on Monocytes and Thereby Stimulates Generation of Cytotoxic Lymphocytes Active against MHC-Negative Tumor Cells.

Sharapova T, Romanova E, Ivanova O, Yashin D, Sashchenko L Int J Mol Sci. 2021; 22(13).

PMID: 34206968 PMC: 8267615. DOI: 10.3390/ijms22136889.

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