Chronic Functional Constipation is Strongly Linked to Vitamin D Deficiency

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2019 Apr 24

PMID 31011257

Citations 23

Authors

Alba Panarese

Francesco Pesce

Piero Porcelli

Giuseppe Riezzo

Palma Aurelia Iacovazzi

Carla Maria Leone

Massimo De Carne

Caterina Mammone Rinaldi

Endrit Shahini

Affiliations

Soon will be listed here.

Abstract

Background: Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not well-defined.

Aim: To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic constipation associated to intestinal motility disorders.

Methods: We performed a prospective case-control study, from May-June to November 2017. Glucose/lactulose breath tests, radiopaque markers (multiple capsule techniques) and wireless motility capsule analysis were used to assess colonic and oro-cecal transit time, after excluding small-intestinal bacterial overgrowth condition. Then, we measured 25-hydroxyvitamin D levels in patients with intestinal motility disorders and we further evaluated the influence of intestinal motility disorders on psychological symptoms/quality of life using validated questionnaires, the Irritable Bowel Syndrome Quality of life (IBS-QOL), the Short Form Health Survey 12, and the Hospital Anxiety and Depression Scale 14 (HADS-14 A and HADS-14 D).

Results: We enrolled 86 patients with chronic functional constipation associated to intestinal motility disorders and 86 matched healthy subjects. Patients with intestinal motility disorders had lower 25-hydroxyvitamin D levels ( < 0.001), and they showed a significant impairment of all health-related quality of life and psychological tests (IBS-QOL, Short Form Health Survey 12-Physical Component Summary, Short Form Health Survey 12-Mental Component Summary, HADS-14 A and HADS-14 D), as compared to the control group ( < 0.001), which significantly correlated with low vitamin D levels ( = - 0.57, < 0.001; = 0.21, = 0.01; = - 0.48, < 0.001; = - 0.57, < 0.001; = - 0.29, < 0.001, respectively). At multivariate analysis vitamin D low levels remained a significant independent risk factor for the occurrence of intestinal motility disorder (odds ratio = 1.19; 95% confidence interval: 1.14-1.26, < 0.001).

Conclusion: Vitamin D deficiency, anxiety and depression symptoms are commonly associated with chronic functional constipation induced by intestinal motility disorders. Vitamin D serum levels should be routinely measured in these patients.

Citing Articles

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Association between dietary vitamin E intake and constipation: NHANES 2005-2010.

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Effect of Physical Activity on the Association Between Diet and Constipation: Evidence From the National Health and Nutrition Examination Survey 2007-2010.

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A survey on functional constipation and its risk factors in older people in Shahreza, Iran.

Amiri M, Hassanzadeh A, Rahimi M J Educ Health Promot. 2024; 13:118.

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