Antioxidants Special Issue: Peroxiredoxin 6 As a Unique Member of the Peroxiredoxin Family

Overview

Journal Antioxidants (Basel)

Date 2019 Apr 24

PMID 31010116

Citations 6

Authors

Aron B Fisher

Affiliations

Soon will be listed here.

Abstract

The peroxiredoxins, first discovered about 30 years ago, are the most recently described family of ubiquitously expressed antioxidant enzymes [...].

Citing Articles

Tumoral Malignancy Decreases Coupled with Higher ROS and Lipid Peroxidation in HCT116 Colon Cancer Cells upon Loss of PRDX6.

Lagal D, Montes-Osuna A, Ortiz-Olivencia A, Arribas-Parejas C, Ortiz-Alcantara A, Pescuezo-Castillo C Antioxidants (Basel). 2024; 13(7).

PMID: 39061949 PMC: 11274330. DOI: 10.3390/antiox13070881.

Unveiling the Significance of Peroxiredoxin 6 in Central Nervous System Disorders.

Xue M, Huang X, Zhu T, Zhang L, Yang H, Shen Y Antioxidants (Basel). 2024; 13(4).

PMID: 38671897 PMC: 11047492. DOI: 10.3390/antiox13040449.

The Role of Phospholipase Activity of Peroxiredoxin 6 in Its Transmembrane Transport and Protective Properties.

Sharapov M, Goncharov R, Parfenyuk S, Glushkova O, Novoselov V Int J Mol Sci. 2022; 23(23).

PMID: 36499590 PMC: 9738660. DOI: 10.3390/ijms232315265.

Peroxiredoxin, Senescence, and Cancer.

Wu M, Deng C, Lo T, Chan K, Li X, Wong C Cells. 2022; 11(11).

PMID: 35681467 PMC: 9179887. DOI: 10.3390/cells11111772.

The Role of Peroxiredoxins in the Regulation of Sepsis.

Aki T, Unuma K, Uemura K Antioxidants (Basel). 2022; 11(1).

PMID: 35052630 PMC: 8773135. DOI: 10.3390/antiox11010126.

References

Lee T, Yu S, Kim S, Kim Y, Choi I, Kang S . Characterization of the murine gene encoding 1-Cys peroxiredoxin and identification of highly homologous genes. Gene. 1999; 234(2):337-44. DOI: 10.1016/s0378-1119(99)00190-0. View

Fisher A, Dodia C, Manevich Y, Chen J, Feinstein S . Phospholipid hydroperoxides are substrates for non-selenium glutathione peroxidase. J Biol Chem. 1999; 274(30):21326-34. DOI: 10.1074/jbc.274.30.21326. View

Fisher A, Dodia C, Feinstein S, Ho Y . Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2. J Lipid Res. 2005; 46(6):1248-56. DOI: 10.1194/jlr.M400499-JLR200. View

Fisher A, Dodia C, Yu K, Manevich Y, Feinstein S . Lung phospholipid metabolism in transgenic mice overexpressing peroxiredoxin 6. Biochim Biophys Acta. 2006; 1761(7):785-92. DOI: 10.1016/j.bbalip.2006.05.009. View

Manevich Y, Reddy K, Shuvaeva T, Feinstein S, Fisher A . Structure and phospholipase function of peroxiredoxin 6: identification of the catalytic triad and its role in phospholipid substrate binding. J Lipid Res. 2007; 48(10):2306-18. DOI: 10.1194/jlr.M700299-JLR200. View

Diet A, Abbas K, Bouton C, Guillon B, Tomasello F, Fourquet S . Regulation of peroxiredoxins by nitric oxide in immunostimulated macrophages. J Biol Chem. 2007; 282(50):36199-205. DOI: 10.1074/jbc.M706420200. View

Lim J, Choi H, Park Y, Nam H, Woo H, Kwon K . Irreversible oxidation of the active-site cysteine of peroxiredoxin to cysteine sulfonic acid for enhanced molecular chaperone activity. J Biol Chem. 2008; 283(43):28873-80. PMC: 2662001. DOI: 10.1074/jbc.M804087200. View

Wu Y, Feinstein S, Manevich Y, Chowdhury I, Pak J, Kazi A . Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A(2) activity. Biochem J. 2009; 419(3):669-79. PMC: 2770719. DOI: 10.1042/BJ20082061. View

Manevich Y, Shuvaeva T, Dodia C, Kazi A, Feinstein S, Fisher A . Binding of peroxiredoxin 6 to substrate determines differential phospholipid hydroperoxide peroxidase and phospholipase A(2) activities. Arch Biochem Biophys. 2009; 485(2):139-49. PMC: 2832859. DOI: 10.1016/j.abb.2009.02.008. View

10.

Fisher A . Peroxiredoxin 6: a bifunctional enzyme with glutathione peroxidase and phospholipase A₂ activities. Antioxid Redox Signal. 2010; 15(3):831-44. PMC: 3125547. DOI: 10.1089/ars.2010.3412. View

11.

Nelson K, Knutson S, Soito L, Klomsiri C, Poole L, Fetrow J . Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis. Proteins. 2011; 79(3):947-64. PMC: 3065352. DOI: 10.1002/prot.22936. View

12.

Rahaman H, Zhou S, Dodia C, Feinstein S, Huang S, Speicher D . Increased phospholipase A2 activity with phosphorylation of peroxiredoxin 6 requires a conformational change in the protein. Biochemistry. 2012; 51(27):5521-30. PMC: 3447995. DOI: 10.1021/bi300380h. View

13.

Rivera-Santiago R, Harper S, Zhou S, Sriswasdi S, Feinstein S, Fisher A . Solution structure of the reduced form of human peroxiredoxin-6 elucidated using zero-length chemical cross-linking and homology modelling. Biochem J. 2015; 468(1):87-98. PMC: 4420655. DOI: 10.1042/BJ20141463. View

14.

Perkins A, Nelson K, Parsonage D, Poole L, Karplus P . Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling. Trends Biochem Sci. 2015; 40(8):435-45. PMC: 4509974. DOI: 10.1016/j.tibs.2015.05.001. View

15.

Fisher A, Dodia C, Sorokina E, Li H, Zhou S, Raabe T . A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6. J Lipid Res. 2016; 57(4):587-96. PMC: 4808767. DOI: 10.1194/jlr.M064758. View

16.

Rhee S . Overview on Peroxiredoxin. Mol Cells. 2016; 39(1):1-5. PMC: 4749868. DOI: 10.14348/molcells.2016.2368. View

17.

Zhou S, Sorokina E, Harper S, Li H, Ralat L, Dodia C . Peroxiredoxin 6 homodimerization and heterodimerization with glutathione S-transferase pi are required for its peroxidase but not phospholipase A2 activity. Free Radic Biol Med. 2016; 94:145-56. PMC: 4844822. DOI: 10.1016/j.freeradbiomed.2016.02.012. View

18.

Sorokina E, Dodia C, Zhou S, Tao J, Gao L, Raabe T . Mutation of Serine 32 to Threonine in Peroxiredoxin 6 Preserves Its Structure and Enzymatic Function but Abolishes Its Trafficking to Lamellar Bodies. J Biol Chem. 2016; 291(17):9268-80. PMC: 4861491. DOI: 10.1074/jbc.M115.698894. View

19.

Vazquez-Medina J, Dodia C, Weng L, Mesaros C, Blair I, Feinstein S . The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages. FASEB J. 2016; 30(8):2885-98. PMC: 4970605. DOI: 10.1096/fj.201500146R. View

20.

Kim K, Lee W, Kim E . Crystal structures of human peroxiredoxin 6 in different oxidation states. Biochem Biophys Res Commun. 2016; 477(4):717-722. DOI: 10.1016/j.bbrc.2016.06.125. View