KIF23 Promotes Gastric Cancer by Stimulating Cell Proliferation

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2019 Apr 23

PMID 31007778

Citations 29

Authors

Xiao-Long Li

Ya-Ming Ji

Rui Song

Xiao-Ning Li

Lan-Shuan Guo

Affiliations

Soon will be listed here.

Abstract

Gastric cancer (GC) is one of the most aggressive malignant tumors with low early diagnosis and high metastasis. Despite progress in treatment, to combat this disease, a better understanding of the underlying mechanisms and novel therapeutic targets is needed. KIF23, which belongs to the KIF family, plays a vital role in various cell processes, such as cytoplasm separation and axon elongation. Nowadays, KIF23 has been found to be highly expressed in multiple tumor tissues and cells, suggesting a potential link between KIF23 and tumorigenesis. Herein, we reported that KIF23 expression was correlated with poor prognosis of gastric cancer and found an association between KIF23 and pTNM stage. An in vitro assay proved that the proliferation of gastric cancer cells was significantly inhibited, which is caused by KIF23 depletion. Additionally, knockdown of KIF23 resulted in a marked inhibition of cell proliferation of gastric cancer in mice, with significant downregulation of Ki67 and PCNA expression. In conclusion, these data indicate that KIF23 is a potential therapeutic target for gastric cancer treatment.

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References

Yang H, Chen Y, Takita J, Soeda E, Piao H, Hayashi Y . Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2. Oncogene. 2001; 20(36):5075-83. DOI: 10.1038/sj.onc.1204456. View

Yu Y, Feng Y . The role of kinesin family proteins in tumorigenesis and progression: potential biomarkers and molecular targets for cancer therapy. Cancer. 2010; 116(22):5150-60. DOI: 10.1002/cncr.25461. View

Valk K, Vooder T, Kolde R, Reintam M, Petzold C, Vilo J . Gene expression profiles of non-small cell lung cancer: survival prediction and new biomarkers. Oncology. 2011; 79(3-4):283-92. DOI: 10.1159/000322116. View

Lee M, Choi D, Park M, Lee M . Gastric cancer: imaging and staging with MDCT based on the 7th AJCC guidelines. Abdom Imaging. 2011; 37(4):531-40. DOI: 10.1007/s00261-011-9780-3. View

Duangtum N, Junking M, Sawasdee N, Cheunsuchon B, Limjindaporn T, Yenchitsomanus P . Human kidney anion exchanger 1 interacts with kinesin family member 3B (KIF3B). Biochem Biophys Res Commun. 2011; 413(1):69-74. DOI: 10.1016/j.bbrc.2011.08.050. View

Takahashi S, Fusaki N, Ohta S, Iwahori Y, Iizuka Y, Inagawa K . Downregulation of KIF23 suppresses glioma proliferation. J Neurooncol. 2011; 106(3):519-29. DOI: 10.1007/s11060-011-0706-2. View

Liljeholm M, Irvine A, Vikberg A, Norberg A, Month S, Sandstrom H . Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, KIF23. Blood. 2013; 121(23):4791-9. DOI: 10.1182/blood-2012-10-461392. View

Fischer M, Grundke I, Sohr S, Quaas M, Hoffmann S, Knorck A . p53 and cell cycle dependent transcription of kinesin family member 23 (KIF23) is controlled via a CHR promoter element bound by DREAM and MMB complexes. PLoS One. 2013; 8(5):e63187. PMC: 3641139. DOI: 10.1371/journal.pone.0063187. View

Qinyu L, Long C, Zhen-dong D, Min-min S, Wei-ze W, Wei-ping Y . FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc. FEBS Lett. 2013; 587(14):2105-11. DOI: 10.1016/j.febslet.2013.05.027. View

10.

Wang G, Gao J, Huang H, Tian Y, Xue L, Wang W . Expression of a LINE-1 endonuclease variant in gastric cancer: its association with clinicopathological parameters. BMC Cancer. 2013; 13:265. PMC: 3670995. DOI: 10.1186/1471-2407-13-265. View

11.

Isakson P, Lystad A, Breen K, Koster G, Stenmark H, Simonsen A . TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy. Autophagy. 2013; 9(12):1955-64. DOI: 10.4161/auto.26085. View

12.

Amieva M, Peek Jr R . Pathobiology of Helicobacter pylori-Induced Gastric Cancer. Gastroenterology. 2015; 150(1):64-78. PMC: 4691563. DOI: 10.1053/j.gastro.2015.09.004. View

13.

Sun X, Jin Z, Song X, Wang J, Li Y, Qian X . Evaluation of KIF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinoma. BMC Cancer. 2015; 15:961. PMC: 4682286. DOI: 10.1186/s12885-015-1987-1. View

14.

Sun L, Zhang C, Yang Z, Wu Y, Wang H, Bao Z . KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4. Oncotarget. 2016; 7(17):24646-55. PMC: 5029730. DOI: 10.18632/oncotarget.8261. View

15.

Iltzsche F, Simon K, Stopp S, Pattschull G, Francke S, Wolter P . An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene. 2016; 36(1):110-121. DOI: 10.1038/onc.2016.181. View

16.

Kato T, Lee D, Wu L, Patel P, Young A, Wada H . Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma. Int J Oncol. 2016; 49(2):448-56. DOI: 10.3892/ijo.2016.3566. View

17.

Han S, Hsu A, Wassef W . An update in the endoscopic management of gastric cancer. Curr Opin Gastroenterol. 2016; 32(6):492-500. DOI: 10.1097/MOG.0000000000000318. View

18.

Karagkounis G, Squires 3rd M, Melis M, Poultsides G, Worhunsky D, Jin L . Predictors and Prognostic Implications of Perioperative Chemotherapy Completion in Gastric Cancer. J Gastrointest Surg. 2017; 21(12):1984-1992. DOI: 10.1007/s11605-017-3594-8. View

19.

Vikberg A, Vooder T, Lokk K, Annilo T, Golovleva I . Mutation analysis and copy number alterations of in non-small-cell lung cancer exhibiting over-expression. Onco Targets Ther. 2017; 10:4969-4979. PMC: 5644594. DOI: 10.2147/OTT.S138420. View

20.

Ye L, Li H, Zhang F, Lv T, Liu H, Song Y . [Expression of KIF23 and Its Prognostic Role in Non-small Cell Lung Cancer:  Analysis Based on the Data-mining of Oncomine]. Zhongguo Fei Ai Za Zhi. 2017; 20(12):822-826. PMC: 5973387. DOI: 10.3779/j.issn.1009-3419.2017.12.05. View