Impact of Respiratory Syncytial Virus-Confirmed Hospitalizations on Caregivers of US Preterm Infants

Overview

Journal Clin Pediatr (Phila)

Publisher Sage Publications

Specialty Pediatrics

Date 2019 Apr 23

PMID 31007050

Citations 11

Authors

Robin M Pokrzywinski

Laura L Swett

Pia S Pannaraj

Jumi Yi

Melissa S Pavilack

Veena R Kumar

Kimmie K McLaurin

Affiliations

Soon will be listed here.

Abstract

This study assessed the impact of respiratory syncytial virus-confirmed hospitalizations (RSVH) on caregivers of high-risk preterm infants. Caregivers for infants born at 29 to 35 weeks' gestational age and hospitalized for confirmed RSV disease responded to measures of self-rated and perceived infant stress (1-7; 7 = very stressful), perceived infant health (0-100; 100 = best imaginable health), and productivity impairment. Data were collected at hospital discharge through 1 month post-discharge. Caregiver responses indicated high stress levels, poor health, and productivity loss were reported at discharge; however, steady improvements were seen through 1 month post-discharge: caregiver-rated stress (from 6 to 2), infant stress (5 to 1), caregiver-perceived infant health (64 to 84), and productivity loss (mothers: 91% to 31%; fathers: 81% to 18%). Qualitative results indicated emotional impact, family routine disruption, financial concerns, and medical concerns persisted at 1 month post-discharge. This study found the caregiver burden of RSVH persists at least 1 month beyond discharge.

Citing Articles

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References

Leader S, Yang H, DeVincenzo J, Jacobson P, Marcin J, Murray D . Time and out-of-pocket costs associated with respiratory syncytial virus hospitalization of infants. Value Health. 2003; 6(2):100-6. DOI: 10.1046/j.1524-4733.2003.00220.x. View

Hodek J, von der Schulenburg J, Mittendorf T . Measuring economic consequences of preterm birth - Methodological recommendations for the evaluation of personal burden on children and their caregivers. Health Econ Rev. 2012; 1(1):6. PMC: 3395039. DOI: 10.1186/2191-1991-1-6. View

. Palivizumab, a Humanized Respiratory Syncytial Virus Monoclonal Antibody, Reduces Hospitalization From Respiratory Syncytial Virus Infection in High-risk Infants. Pediatrics. 1998; 102(3):531-7. View

Mitchell I, Defoy I, Grubb E . Burden of Respiratory Syncytial Virus Hospitalizations in Canada. Can Respir J. 2018; 2017:4521302. PMC: 5697123. DOI: 10.1155/2017/4521302. View

Franck L, Wray J, Gay C, Dearmun A, Lee K, Cooper B . Predictors of parent post-traumatic stress symptoms after child hospitalization on general pediatric wards: a prospective cohort study. Int J Nurs Stud. 2014; 52(1):10-21. DOI: 10.1016/j.ijnurstu.2014.06.011. View

Reilly M, Zbrozek A, Dukes E . The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics. 1993; 4(5):353-65. DOI: 10.2165/00019053-199304050-00006. View

. Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection. Pediatrics. 2014; 134(2):415-20. DOI: 10.1542/peds.2014-1665. View

Cousino M, Hazen R . Parenting stress among caregivers of children with chronic illness: a systematic review. J Pediatr Psychol. 2013; 38(8):809-28. DOI: 10.1093/jpepsy/jst049. View

Anderson E, Krilov L, DeVincenzo J, Checchia P, Halasa N, Simoes E . SENTINEL1: An Observational Study of Respiratory Syncytial Virus Hospitalizations among U.S. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis. Am J Perinatol. 2016; 34(1):51-61. DOI: 10.1055/s-0036-1584147. View

10.

Spear M, Leef K, Epps S, Locke R . Family reactions during infants' hospitalization in the neonatal intensive care unit. Am J Perinatol. 2002; 19(4):205-13. DOI: 10.1055/s-2002-28484. View

11.

Blanken M, Rovers M, Molenaar J, Winkler-Seinstra P, Meijer A, Kimpen J . Respiratory syncytial virus and recurrent wheeze in healthy preterm infants. N Engl J Med. 2013; 368(19):1791-9. DOI: 10.1056/NEJMoa1211917. View

12.

Miles M, Burchinal P, Holditch-Davis D, Brunssen S, Wilson S . Perceptions of stress, worry, and support in Black and White mothers of hospitalized, medically fragile infants. J Pediatr Nurs. 2002; 17(2):82-8. DOI: 10.1053/jpdn.2002.124125. View

13.

Boyce T, Mellen B, Mitchel Jr E, Wright P, Griffin M . Rates of hospitalization for respiratory syncytial virus infection among children in medicaid. J Pediatr. 2000; 137(6):865-70. DOI: 10.1067/mpd.2000.110531. View

14.

Hall C, Weinberg G, Blumkin A, Edwards K, Staat M, Schultz A . Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age. Pediatrics. 2013; 132(2):e341-8. DOI: 10.1542/peds.2013-0303. View

15.

. From the American Academy of Pediatrics: Policy statements--Modified recommendations for use of palivizumab for prevention of respiratory syncytial virus infections. Pediatrics. 2009; 124(6):1694-701. DOI: 10.1542/peds.2009-2345. View

16.

Franck L, Cox S, Allen A, Winter I . Parental concern and distress about infant pain. Arch Dis Child Fetal Neonatal Ed. 2004; 89(1):F71-5. PMC: 1721639. DOI: 10.1136/fn.89.1.f71. View

17.

Yael Kopacz N, Predeger E, Kelley C . Experiences of Alaskan parents with children hospitalized for respiratory syncytial virus treatment. J Pediatr Nurs. 2013; 28(6):e19-21. DOI: 10.1016/j.pedn.2013.01.009. View

18.

Leidy N, Margolis M, Marcin J, Flynn J, Frankel L, Johnson S . The impact of severe respiratory syncytial virus on the child, caregiver, and family during hospitalization and recovery. Pediatrics. 2005; 115(6):1536-46. DOI: 10.1542/peds.2004-1149. View

19.

Feltes T, Cabalka A, Meissner H, Piazza F, Carlin D, Top Jr F . Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease. J Pediatr. 2003; 143(4):532-40. DOI: 10.1067/s0022-3476(03)00454-2. View

20.

Leader S, Kohlhase K . Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000. J Pediatr. 2003; 143(5 Suppl):S127-32. DOI: 10.1067/s0022-3476(03)00510-9. View