Where Are We Today with Infection Among Healthy Children in Saudi Arabia?

Overview

Journal Saudi J Gastroenterol

Specialty Gastroenterology

Date 2019 Apr 23

PMID 31006713

Citations 12

Authors

Abdulrahman A Al-Hussaini

Abdullah N Al Jurayyan

Salman M Bashir

Dayel AlShahrani

Affiliations

Soon will be listed here.

Abstract

Background/aims: The available studies on Helicobacter pylori (H. pylori) prevalence among healthy asymptomatic population across Saudi Arabia suffers from significant limitations. We conducted this large population-based study to estimate the H. pylori seropositivity rate among apparently healthy children in Saudi Arabia, using anti-H. pylori immunoglobulin A (IgA) and IgG serology tests, and to study the influence of H. pylori infection on growth.

Materials And Methods: We conducted a cross-sectional study to screen apparently healthy school aged Saudi children (aged 6-15 years), attending primary and intermediate schools in Riyadh between 2014 and 2016, for H. pylori seropositivity by checking for the presence of anti-H. pylori IgG and IgA antibodies in serum specimens.

Results: Out of 3551 serum specimens, 1413 cases tested seropositive for H. pylori organism (40%): 430 (12.2%) were both IgG and IgA positive, 212 (6%) and 771 (21.7%) cases showed isolated positivity for IgG or IgA, respectively. Male gender, older age, lower levels of socioeconomic status (SES), and family members >10 were significantly associated with H. pylori seropositivity. The proportion of participants with short stature was significantly more in the H. pylori seropositive group than the seronegative group (OR1.249, confidence interval [1.020-1.531], P= 0.033). There was no significant association between H. pylori seropositivity and gastrointestinal symptoms.

Conclusion: The prevalence of H. pylori seropositivity among apparently healthy Saudi children (40%) is intermediate compared with that in developed and developing countries. The Saudi pediatric population shows a predominant IgA-type immunological response to H. pylori infection.

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References

Evans D, Abdulghani M, Adam E, Evans Jr D, Malaty H, Graham D . Prevalence of Helicobacter (formerly Campylobacter) pylori infection in Saudia Arabia, and comparison of those with and without upper gastrointestinal symptoms. Am J Gastroenterol. 1990; 85(8):944-8. View

Kuipers E, Pena A, van Kamp G, Uyterlinde A, Pals G, Pels N . Seroconversion for Helicobacter pylori. Lancet. 1993; 342(8867):328-31. DOI: 10.1016/0140-6736(93)91473-y. View

Khan A . An age- and gender-specific analysis of H. Pylori infection. Ann Saudi Med. 2007; 18(1):6-8. DOI: 10.5144/0256-4947.1998.6. View

Quinonez J, Chew F, Torres O, Begue R . Nutritional status of Helicobacter pylori-infected children in Guatemala as compared with uninfected peers. Am J Trop Med Hyg. 1999; 61(3):395-8. DOI: 10.4269/ajtmh.1999.61.395. View

Nakayama Y, Lin Y, Hongo M, Hidaka H, Kikuchi S . Helicobacter pylori infection and its related factors in junior high school students in Nagano Prefecture, Japan. Helicobacter. 2016; 22(2). DOI: 10.1111/hel.12363. View

Rashed R, Ayoola E, Mofleh I, Chowdhury M, Mahmood K, Faleh F . Helicobacter pylori and dyspepsia in an Arab population. Trop Geogr Med. 1992; 44(4):304-7. View

Zabala Torrres B, Lucero Y, Lagomarcino A, Orellana-Manzano A, George S, Torres J . Review: Prevalence and dynamics of Helicobacter pylori infection during childhood. Helicobacter. 2017; 22(5). DOI: 10.1111/hel.12399. View

Ashorn M, Maki M, Hallstrom M, Uhari M, Akerblom H, Viikari J . Helicobacter pylori infection in Finnish children and adolescents. A serologic cross-sectional and follow-up study. Scand J Gastroenterol. 1995; 30(9):876-9. DOI: 10.3109/00365529509101594. View

Cataldo F, Simpore J, Greco P, Ilboudo D, Musumeci S . Helicobacter pylori infection in Burkina Faso: an enigma within an enigma. Dig Liver Dis. 2004; 36(9):589-93. DOI: 10.1016/j.dld.2004.05.005. View

10.

Sood M, Joshi S, Akobeng A, Mitchell J, Thomas A . Growth in children with Helicobacter pylori infection and dyspepsia. Arch Dis Child. 2005; 90(10):1025-8. PMC: 1720122. DOI: 10.1136/adc.2004.066803. View

11.

Al Faleh F, Ali S, Aljebreen A, Alhammad E, Abdo A . Seroprevalence rates of Helicobacter pylori and viral hepatitis A among adolescents in three regions of the Kingdom of Saudi Arabia: is there any correlation?. Helicobacter. 2010; 15(6):532-7. DOI: 10.1111/j.1523-5378.2010.00800.x. View

12.

Spee L, Madderom M, Pijpers M, van Leeuwen Y, Berger M . Association between helicobacter pylori and gastrointestinal symptoms in children. Pediatrics. 2010; 125(3):e651-69. DOI: 10.1542/peds.2010-0941. View

13.

Lee J, Choi K, Jung H, Baik G, Park J, Kim S . Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016. Helicobacter. 2018; 23(2):e12463. PMC: 5900911. DOI: 10.1111/hel.12463. View

14.

Parsonnet J, Blaser M, Perez-Perez G, Tauxe R . Symptoms and risk factors of Helicobacter pylori infection in a cohort of epidemiologists. Gastroenterology. 1992; 102(1):41-6. DOI: 10.1016/0016-5085(92)91782-y. View

15.

Bruce M, Maaroos H . Epidemiology of Helicobacter pylori infection. Helicobacter. 2008; 13 Suppl 1:1-6. DOI: 10.1111/j.1523-5378.2008.00631.x. View

16.

Eusebi L, Zagari R, Bazzoli F . Epidemiology of Helicobacter pylori infection. Helicobacter. 2014; 19 Suppl 1:1-5. DOI: 10.1111/hel.12165. View

17.

Dinic M, Tasic G, Stankovic-dordevic D, Otasevic L, Tasic M, Karanikolic A . Serum anti-Helicobacter pylori IgA and IgG antibodies in asymptomatic children in Serbia. Scand J Infect Dis. 2007; 39(4):303-7. DOI: 10.1080/00365540601034741. View

18.

Tsuda M, Asaka M, Kato M, Matsushima R, Fujimori K, Akino K . Effect on Helicobacter pylori eradication therapy against gastric cancer in Japan. Helicobacter. 2017; 22(5). PMC: 5655764. DOI: 10.1111/hel.12415. View

19.

Satti M, Al-Freihi H, Ibrahim E, Al-Gindan Y, Al-Quorain A, Al-Ghassab G . Helicobacter pylori-associated upper gastrointestinal disease in Saudi Arabia: a pathologic evaluation of 298 endoscopic biopsies from 201 consecutive patients. Am J Gastroenterol. 1990; 85(5):527-34. View

20.

El-Mouzan M, Abdullah A, Al-Mofleh I . Gastritis in Saudi Arab children. Saudi Med J. 2005; 26(4):576-9. View