The Role of Intestinal Microbiota in the Pathogenesis of Colorectal Carcinoma

Overview

Journal Folia Microbiol (Praha)

Publisher Springer

Specialty Microbiology

Date 2019 Apr 20

PMID 31001762

Citations 10

Authors

Jozef Kuzma

Dittmar Chmelar

Michal Hajek

Alexandra Lochmanova

Ivan ciznar

Miroslav Rozloznik

Miloslav Klugar

Affiliations

Soon will be listed here.

Abstract

The symbiotic relationship between intestinal microbiota and the host is a major mechanism of prevention against the development of chronic and metabolic diseases. The intestinal microbiota provides several physiological functions of the organism from the creation of a natural functional barrier with a subsequent immunostimulatory activity up to affecting the energy metabolism of the host. Disruption of physiological intestinal microbiota is reported as one of the major etiological factors of initiation and progression of colorectal carcinoma (CRC). Chronic low-grade inflammation is associated with the development of CRC, through the production of inflammatory cytokines and reactive oxygen species. CRC occurs in association with high-protein and high-fat diets in combination with low-fiber intake. The problem of intestinal dysbiosis and oncological diseases is a multidisciplinary problem and it is necessary to focus on several fields of medicine such as public health, clinical pharmacology, and internal medicine. The aim of this review is describing the role of gut dysbiosis in pathogenesis of colorectal carcinoma.

Citing Articles

Microbiome and Mucosal Immunity in the Intestinal Tract.

Ahrend H, Buchholtz A, Stope M In Vivo. 2024; 39(1):17-24.

PMID: 39740876 PMC: 11705094. DOI: 10.21873/invivo.13801.

Long-chain polyunsaturated fatty acids influence colorectal cancer progression via the interactions between the intestinal microflora and the macrophages.

Peng D, Wang Y, Yao Y, Yang Z, Wu S, Zeng K Mol Cell Biochem. 2024; 479(11):2895-2906.

PMID: 38217838 DOI: 10.1007/s11010-023-04904-y.

Microbiome modulation in the prevention and management of colorectal cancer: a systematic review of clinical interventions.

Fratila T, Ismaiel A, Dumitrascu D Med Pharm Rep. 2023; 96(2):131-145.

PMID: 37197270 PMC: 10184528. DOI: 10.15386/mpr-2526.

Biomarkers of coordinate metabolic reprogramming and the construction of a co-expression network in colorectal cancer.

Lin L, Zeng X, Liang S, Wang Y, Dai X, Sun Y Ann Transl Med. 2022; 10(20):1115.

PMID: 36388835 PMC: 9652529. DOI: 10.21037/atm-22-4767.

Intestinal Permeability and Depression in Patients with Inflammatory Bowel Disease.

Iordache M, Tocia C, Aschie M, Dumitru A, Manea M, Cozaru G J Clin Med. 2022; 11(17).

PMID: 36079050 PMC: 9457405. DOI: 10.3390/jcm11175121.

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