Neutrophil Properties in Healthy and Leishmania Infantum-naturally Infected Dogs

Overview

Journal Sci Rep

Specialty Science

Date 2019 Apr 20

PMID 31000764

Citations 11

Authors

Amanda Brito Wardini

Lucia Helena Pinto-da-Silva

Natalia Rocha Nadaes

Michelle Tanny Nascimento

Bruno Mendes Roatt

Alexandre Barbosa Reis

Kelvinson Fernandes Viana

Rodolfo Cordeiro Giunchetti

Elvira Maria Saraiva

Affiliations

Soon will be listed here.

Abstract

Visceral leishmaniasis is a chronic disease that affects humans and dogs as well. Dogs, the domestic reservoir of Leishmania, play a central role in the transmission of visceral leishmaniasis, the most severe form of this disease. Neutrophils are the most abundant leukocytes in blood and interact with the parasite after infection. Here, we evaluate the effector properties of neutrophils from healthy and naturally Leishmania infantum-infected dogs. Our results showed that the parasite induced neutrophil extracellular trap (NET) release from neutrophils in both groups. Additionally, phagocytosis and NETs contributed differently to parasite killing by neutrophils from healthy and infected animals, and IFN-γ, IL-8, IL-4 and TNF-α production by neutrophils from both groups were differentially modulated by the parasite. Our results contribute to a better understanding of the complex role played by neutrophils in canine visceral leishmaniasis, which may favor the development of more effective therapies.

Citing Articles

Elucidating the role played by bone marrow in visceral leishmaniasis.

Veras P, de Santana M, Brodskyn C, Fraga D, Solca M, De Menezes J Front Cell Infect Microbiol. 2023; 13:1261074.

PMID: 37860064 PMC: 10582953. DOI: 10.3389/fcimb.2023.1261074.

Exploring the Relationship between Neutrophil Activation and Different States of Canine Infection: Nitroblue Tetrazolium Test and IFN-γ.

Blasi-Brugue C, Martinez-Florez I, Baxarias M, Del Rio-Velasco J, Solano-Gallego L Vet Sci. 2023; 10(9).

PMID: 37756094 PMC: 10535614. DOI: 10.3390/vetsci10090572.

Axenic Amastigotes Induce Human Neutrophil Extracellular Traps and Resist NET-Mediated Killing.

Oliveira T, Oliveira-Silva J, Linhares-Lacerda L, Fraga-Junior V, Benjamim C, Guimaraes-Costa A Trop Med Infect Dis. 2023; 8(7).

PMID: 37505632 PMC: 10385766. DOI: 10.3390/tropicalmed8070336.

Immunological and genomic characterization of Ibizan Hound dogs in an endemic Leishmania infantum region.

Alvarez L, Marin-Garcia P, Llobat L Parasit Vectors. 2022; 15(1):445.

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The emerging role of neutrophil extracellular traps in fungal infection.

Liang C, Lian N, Li M Front Cell Infect Microbiol. 2022; 12:900895.

PMID: 36034717 PMC: 9411525. DOI: 10.3389/fcimb.2022.900895.

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