The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice

Overview

Journal Nutrients

Date 2019 Apr 19

PMID 30995790

Citations 6

Authors

Huiling Chen

Qing Huang

Shunjia Zhang

Kaiqiang Hu

Wenxiang Xiong

Lingyun Xiao

Renhuai Cong

Qingfei Liu

Zhao Wang

Affiliations

Soon will be listed here.

Abstract

Major depressive disorder (MDD) is a chronic mental disorder characterized by mixed symptoms and complex pathogenesis. With long history of practical application, traditional Chinese medicine (TCM) offers many herbs for the treatment and rehabilitation of chronic disease. In this study, we developed a modified Chinese herbal formula using Willd, and Semen (PAPZ), based on an ancient TCM prescription. The antidepressant effects of PAPZ were investigated with a corticosterone (CORT) model of depression in mice. Our results showed that administration of PAPZ ameliorated depression-like phenotypes in the CORT model. An anatomic study showed that chronic PAPZ administration upregulated the protein expression of brain-derived neurotrophic factor (BDNF) in hippocampal tissue. The enzyme activity of superoxide dismutase was enhanced in hippocampal tissue, in line with a decreased malondialdehyde level. Taken together, these findings suggested that PAPZ has therapeutic effects in a mice depression model through increasing protein expression of BDNF and improving the anti-oxidation ability of the brain.

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