TRPM7, Magnesium, and Signaling

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Apr 19

PMID 30995736

Citations 72

Authors

Zhi-Guo Zou

Francisco J Rios

Augusto C Montezano

Rhian M Touyz

Affiliations

Soon will be listed here.

Abstract

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed chanzyme that possesses an ion channel permeable to the divalent cations Mg, Ca, and Zn, and an α-kinase that phosphorylates downstream substrates. TRPM7 and its homologue TRPM6 have been implicated in a variety of cellular functions and is critically associated with intracellular signaling, including receptor tyrosine kinase (RTK)-mediated pathways. Emerging evidence indicates that growth factors, such as EGF and VEGF, signal through their RTKs, which regulate activity of TRPM6 and TRPM7. TRPM6 is primarily an epithelial-associated channel, while TRPM7 is more ubiquitous. In this review we focus on TRPM7 and its association with growth factors, RTKs, and downstream kinase signaling. We also highlight how interplay between TRPM7, Mg and signaling kinases influences cell function in physiological and pathological conditions, such as cancer and preeclampsia.

Citing Articles

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TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner.

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TRPM channels in human cancers: regulatory mechanism and therapeutic prospects.

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