Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2019 Apr 17

PMID 30986998

Citations 56

Authors

Maria Fiore

Gea Oliveri Conti

Rosario Caltabiano

Antonino Buffone

Pietro Zuccarello

Livia Cormaci

Matteo Angelo Cannizzaro

Margherita Ferrante

Affiliations

Soon will be listed here.

Abstract

Environmental factors are recognized as risk factors of thyroid cancer in humans. Exposure to radiation, both from nuclear weapon or fallout or medical radiation, and to some organic and inorganic chemical toxicants represent a worldwide public health issue for their proven carcinogenicity. Halogenated compounds, such as organochlorines and pesticides, are able to disrupt thyroid function. Polychlorinated biphenyls and their metabolites and polybrominated diethyl ethers bind to thyroid, transport proteins, replace thyroxin, and disrupt thyroid function as phthalates and bisphenolates do, highly mimicking thyroid hormones. A better knowledge of environmental risks represents a very important tool for cancer prevention through true risks prevention and management. This approach is very important because of the epigenetic origin's theory of cancer. Therefore, the aim of this review was study the association between environmental agents and thyroid cancer promotion.

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