Evaluation of Antibacterial Activity of Zinc-Doped Hydroxyapatite Colloids and Dispersion Stability Using Ultrasounds

Overview

Journal Nanomaterials (Basel)

Date 2019 Apr 17

PMID 30986971

Citations 29

Authors

Daniela Predoi

Simona Liliana Iconaru

Mihai Valentin Predoi

Mikael Motelica-Heino

Regis Guegan

Nicolas Buton

Affiliations

Soon will be listed here.

Abstract

This study proves that the new developed zinc-doped hydroxyapatite (ZnHAp) colloids by an adapted sol-gel method can be widely used in the pharmaceutical, medical, and environmental industries. ZnHAp nanoparticles were stabilized in an aqueous solution, and their colloidal dispersions have been characterized by different techniques. Scanning Electron Microscopy (SEM) was used to get information on the morphology and composition of the investigated samples. Energy-dispersive X-ray spectroscopy (EDX) analysis confirmed the elemental compositions of ZnHAp colloidal dispersions. The homogeneous and uniform distribution of constituent elements (zinc, calcium, phosphorus, oxygen) was highlighted by the obtained elemental mapping results. The X-ray diffraction (XRD) results of the obtained samples showed a single phase corresponding to the hexagonal hydroxyapatite. The characteristic bands of the hydroxyapatite structure were also evidenced by Fourier-transform infrared spectroscopy (FTIR) analysis. For a stability assessment of the colloidal system, ζ-potential for the ZnHAp dispersions was estimated. Dynamic light scattering (DLS) was used to determine particles dispersion and hydrodynamic diameter (D). The goal of this study was to provide for the first time information on the stability of ZnHAp particles in solutions evaluated by non-destructive ultrasound-based technique. In this work, the influence of the ZnHAp colloidal solutions stability on the development of bacteria, such as () and (), was also established for the first time. The antimicrobial activity of ZnHAp solutions was strongly influenced by both the stability of the solutions and the amount of Zn.

Citing Articles

New Nanobioceramics Based on Hydroxyapatite for Biomedical Applications: Stability and Properties.

Ciobanu C, Predoi D, Iconaru S, Negrila C, Leduc D, Ghegoiu L Nanomaterials (Basel). 2025; 15(3).

PMID: 39940201 PMC: 11820604. DOI: 10.3390/nano15030224.

Development of Novel Biocomposites with Antimicrobial-Activity-Based Magnesium-Doped Hydroxyapatite with Amoxicillin.

Cimpeanu C, Predoi D, Ciobanu C, Iconaru S, Rokosz K, Predoi M Antibiotics (Basel). 2024; 13(10).

PMID: 39452229 PMC: 11504330. DOI: 10.3390/antibiotics13100963.

Novel Antimicrobial Agents Based on Zinc-Doped Hydroxyapatite Loaded with Tetracycline.

Iconaru S, Predoi D, Ciobanu C, Negrila C, Trusca R, Raaen S Antibiotics (Basel). 2024; 13(9).

PMID: 39334978 PMC: 11428947. DOI: 10.3390/antibiotics13090803.

Physico-Chemical and Biological Features of Fluorine-Substituted Hydroxyapatite Suspensions.

Ciobanu C, Predoi D, Iconaru S, Predoi M, Rokosz K, Raaen S Materials (Basel). 2024; 17(14).

PMID: 39063697 PMC: 11277939. DOI: 10.3390/ma17143404.

In Vitro Characterization of Hydroxyapatite-Based Coatings Doped with Mg or Zn Electrochemically Deposited on Nanostructured Titanium.

Vranceanu D, Ungureanu E, Ionescu I, Parau A, Pruna V, Titorencu I Biomimetics (Basel). 2024; 9(4).

PMID: 38667255 PMC: 11047857. DOI: 10.3390/biomimetics9040244.

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