Effect of Carvacrol on Pulmonary Function Tests, and Total and Differential White Blood Cell Counts in Healthy Volunteers: A Randomized Clinical Trial

Overview

Journal Avicenna J Phytomed

Publisher Mashhad University of Medical Sciences

Date 2019 Apr 16

PMID 30984578

Citations 2

Authors

Vahideh Ghorani

Marzie Boskabady

Mohammad Hossein Boskabady

Affiliations

Soon will be listed here.

Abstract

Objective: This is the first study to evaluate the effect of carvacrol on pulmonary function tests (PFT), and total and differential white blood cell (WBC) counts in healthy volunteers.

Materials And Methods: Thirty healthy volunteers were recruited based on the inclusion and exclusion criteria. The subjects were treated with two doses of carvacrol (1 and 2 mg/kg/day) for 1 month. Total and differential WBC counts and PFT were examined before and after the treatment period.

Results: There were no statistically significant differences in terms of total and differential WBC counts between pre and post-treatment with the two doses of carvacrol. Also, results of PFT tests indicated that administration of 1 mg/kg/day carvacrol had no effect on PFT parameters when comparing post-treatment values with pre-treatment values. Treatment with 2 mg/kg/day carvacrol for 1 month increased forced expiratory volume in first second (FEV) (p<0.05). However, the changes in total and differential WBC counts as well as PFT values after 1-month treatment were not significantly different between two groups.

Conclusion: The results of this study indicated that treatment of healthy individuals with 1 and 2 mg/kg carvacrol for 1 month has no negative effects on total and differential WBC counts nor PFT values.

Citing Articles

Carvacrol: Innovative Synthesis Pathways and Overview of its Patented Applications.

El Boukhari R, Fatimi A Recent Pat Biotechnol. 2025; 19(1):53-68.

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Carvacrol attenuated neuroinflammation, oxidative stress and depression and anxiety like behaviors in lipopolysaccharide-challenged rats.

Salmani H, Hakimi Z, Arab Z, Marefati N, Mahdinezhad M, RezaeiGolestan A Avicenna J Phytomed. 2022; 12(5):514-526.

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Effect of Carvacrol, TRP Channels Modulator, on Cardiac Electrical Activity.

Almanaityte M, Jurevicius J, Macianskiene R Biomed Res Int. 2020; 2020:6456805.

PMID: 32337263 PMC: 7166271. DOI: 10.1155/2020/6456805.

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