Predominant Determinants of Delayed Tuberculosis Sputum Conversion in Indonesia

Overview

Journal Indian J Community Med

Date 2019 Apr 16

PMID 30983715

Citations 7

Authors

Dyah Wulan Sumekar Rengganis Wardani

Endro Prasetyo Wahono

Affiliations

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Abstract

Context: Sputum conversion in the first 2 months of tuberculosis (TB) treatment is closely related to successful treatment and a decrease in the likelihood of relapse. In 2015, there were 76% high TB burden countries with low rate of TB successful treatment.

Aims: This study aims to evaluate the correlation between delayed sputum conversion and several determinants including social determinants, smoking, malnutrition, and type II diabetes mellitus (DM).

Settings And Design: A case-control approach was used to study the potential determinants. A case sample group consisted of smear-positive TB patients with delayed sputum conversion (31 patients) at community health centers in Bandar Lampung, Indonesia. Meanwhile, a control sample group consisted of smear-positive TB patients with sputum conversion (62 patients).

Subjects And Methods: Primary data consisted of social determinants and smoking, were collected through in-depth interviews. Meanwhile, secondary data consisted of malnutrition, DM, and sputum conversion were obtained from the medical record.

Statistical Analysis Used: Data were analyzed using Chi-square and multivariate logistic regression.

Results: Low education (odds ratio [OR]: 5.313; 95% (confidence interval [CI]: 1.711-16.503), low social class (OR: 4.993; 95% CI: 1.430-17.430), smoking (OR: 7.457; 95% CI: 1.757-31.640), and DM (OR: 7.168; 95% CI: 1.746-29.431) influenced delayed sputum conversion.

Conclusions: TB control programs in high TB burden countries with low rate of TB successful treatment, should be integrate TB treatment education, smoking cessation programs and follow-up treatments for TB patients with DM to improve the probability of sputum conversion and successful treatment.

Citing Articles

Risk factors for delayed sputum conversion: A qualitative case study from the person-in-charge of TB program's perspectives.

Wardani D, Pramesona B, Septiana T, Soemarwoto R J Public Health Res. 2023; 12(4):22799036231208355.

PMID: 37901194 PMC: 10605690. DOI: 10.1177/22799036231208355.

Is Tobacco Use Associated With Risk of Recurrence and Mortality Among People With TB?: A Systematic Review and Meta-Analysis.

Vidyasagaran A, Readshaw A, Boeckmann M, Jarde A, Siddiqui F, Marshall A Chest. 2023; 165(1):22-47.

PMID: 37652295 PMC: 10790178. DOI: 10.1016/j.chest.2023.08.021.

Treatment outcomes of extended versus nonextended intensive phase in pulmonary tuberculosis smear positive patients with delayed sputum smear conversion: A retrospective cohort study at primary care clinics in Kota Kinabalu.

Atiqah A, Tong S, Nadirah S Malays Fam Physician. 2023; 18:2.

PMID: 36969335 PMC: 10038155. DOI: 10.51866/oa.191.

Malnutrition assessment methods in adult patients with tuberculosis: a systematic review.

Ter Beek L, Bolhuis M, Jager-Wittenaar H, Brijan R, Sturkenboom M, Kerstjens H BMJ Open. 2022; 11(12):e049777.

PMID: 35344503 PMC: 8719177. DOI: 10.1136/bmjopen-2021-049777.

Epidemiology and Risk Factors of Delayed Sputum Smear Conversion in Malaysian Aborigines with Smear-Positive Pulmonary Tuberculosis.

Ibrahim M, Nik Husain N, Daud A, Chinnayah T Int J Environ Res Public Health. 2022; 19(4).

PMID: 35206552 PMC: 8872111. DOI: 10.3390/ijerph19042365.

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