Cell Circuits and Niches Controlling B Cell Development

Overview

Journal Immunol Rev

Specialties Allergy & Immunology
General Surgery

Date 2019 Apr 13

PMID 30977190

Citations 39

Authors

Sandra Zehentmeier

Joao P Pereira

Affiliations

Soon will be listed here.

Abstract

Studies over the last decade uncovered overlapping niches for hematopoietic stem cells (HSCs), multipotent progenitor cells, common lymphoid progenitors, and early B cell progenitors. HSC and lymphoid niches are predominantly composed by mesenchymal progenitor cells (MPCs) and by a small subset of endothelial cells. Niche cells create specialized microenvironments through the concomitant production of short-range acting cell-fate determining cytokines such as interleukin (IL)-7 and stem cell factor and the potent chemoattractant C-X-C motif chemokine ligand 12. This type of cellular organization allows for the cross-talk between hematopoietic stem and progenitor cells with niche cells, such that niche cell activity can be regulated by the quality and quantity of hematopoietic progenitors being produced. For example, preleukemic B cell progenitors and preB acute lymphoblastic leukemias interact directly with MPCs, and downregulate IL-7 expression and the production of non-leukemic lymphoid cells. In this review, we discuss a novel model of B cell development that is centered on cellular circuits formed between B cell progenitors and lymphopoietic niches.

Citing Articles

B cells in non-lymphoid tissues.

Samiea A, Celis G, Yadav R, Rodda L, Moreau J Nat Rev Immunol. 2025; .

PMID: 39910240 DOI: 10.1038/s41577-025-01137-6.

How the bone microenvironment shapes the pre-metastatic niche and metastasis.

Jackett K, Browne A, Aber E, Clements M, Kaplan R Nat Cancer. 2024; 5(12):1800-1814.

PMID: 39672975 DOI: 10.1038/s43018-024-00854-6.

Tviblindi algorithm identifies branching developmental trajectories of human B-cell development and describes abnormalities in RAG-1 and WAS patients.

Bakardjieva M, Pelak O, Wentink M, Glier H, Novak D, Stancikova J Eur J Immunol. 2024; 54(12):e2451004.

PMID: 39235410 PMC: 11628918. DOI: 10.1002/eji.202451004.

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity.

Jing Z, Galbo P, Ovando L, Demouth M, Welte S, Park R Elife. 2024; 12.

PMID: 38896451 PMC: 11186632. DOI: 10.7554/eLife.89712.

From Marrow to Bone and Fat: Exploring the Multifaceted Roles of Leptin Receptor Positive Bone Marrow Mesenchymal Stromal Cells.

Prasad P, Cancelas J Cells. 2024; 13(11.

PMID: 38891042 PMC: 11171870. DOI: 10.3390/cells13110910.

References

Calvi L, Adams G, Weibrecht K, Weber J, Olson D, Knight M . Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003; 425(6960):841-6. DOI: 10.1038/nature02040. View

Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J . Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood. 2007; 109(9):3706-12. DOI: 10.1182/blood-2006-08-041384. View

Manz R, Thiel A, Radbruch A . Lifetime of plasma cells in the bone marrow. Nature. 1997; 388(6638):133-4. DOI: 10.1038/40540. View

Pereira J, An J, Xu Y, Huang Y, Cyster J . Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids. Nat Immunol. 2009; 10(4):403-11. PMC: 2768754. DOI: 10.1038/ni.1710. View

Egawa T, Kawabata K, Kawamoto H, Amada K, Okamoto R, Fujii N . The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor. Immunity. 2001; 15(2):323-34. DOI: 10.1016/s1074-7613(01)00185-6. View

Inlay M, Bhattacharya D, Sahoo D, Serwold T, Seita J, Karsunky H . Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev. 2009; 23(20):2376-81. PMC: 2764492. DOI: 10.1101/gad.1836009. View

Lieber M . The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem. 2010; 79:181-211. PMC: 3079308. DOI: 10.1146/annurev.biochem.052308.093131. View

Mazzucchelli R, Warming S, Lawrence S, Ishii M, Abshari M, Washington A . Visualization and identification of IL-7 producing cells in reporter mice. PLoS One. 2009; 4(11):e7637. PMC: 2770321. DOI: 10.1371/journal.pone.0007637. View

Parker M, Licence S, Erlandsson L, Galler G, Chakalova L, Osborne C . The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription. EMBO J. 2005; 24(22):3895-905. PMC: 1283949. DOI: 10.1038/sj.emboj.7600850. View

10.

Nie Y, Han Y, Zou Y . CXCR4 is required for the quiescence of primitive hematopoietic cells. J Exp Med. 2008; 205(4):777-83. PMC: 2292218. DOI: 10.1084/jem.20072513. View

11.

Glodek A, Honczarenko M, Le Y, Campbell J, Silberstein L . Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesis. J Exp Med. 2003; 197(4):461-73. PMC: 2193869. DOI: 10.1084/jem.20021477. View

12.

Nie Y, Waite J, Brewer F, Sunshine M, Littman D, Zou Y . The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med. 2004; 200(9):1145-56. PMC: 2211858. DOI: 10.1084/jem.20041185. View

13.

Fisher A, Burdet C, Lemeur M, Haasner D, Gerber P, Ceredig R . Lymphoproliferative disorders in an IL-7 transgenic mouse line. Leukemia. 1993; 7 Suppl 2:S66-8. View

14.

Walkley C, Olsen G, Dworkin S, Fabb S, Swann J, McArthur G . A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell. 2007; 129(6):1097-110. PMC: 1974882. DOI: 10.1016/j.cell.2007.05.014. View

15.

Park L, Martin U, Garka K, Gliniak B, Di Santo J, Muller W . Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med. 2000; 192(5):659-70. PMC: 2193276. DOI: 10.1084/jem.192.5.659. View

16.

Nevius E, Pinho F, Dhodapkar M, Jin H, Nadrah K, Horowitz M . Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. J Exp Med. 2015; 212(11):1931-46. PMC: 4612084. DOI: 10.1084/jem.20150088. View

17.

Rolink A, Winkler T, Melchers F, Andersson J . Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment. J Exp Med. 2000; 191(1):23-32. PMC: 2195801. DOI: 10.1084/jem.191.1.23. View

18.

Hudson G, YOFFEY J . Ultrastructure of reticuloendothelial elements in guinea-pig bone marrow. J Anat. 1968; 103(Pt 3):515-25. PMC: 1231668. View

19.

Serbina N, Pamer E . Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat Immunol. 2006; 7(3):311-7. DOI: 10.1038/ni1309. View

20.

Allende M, Tuymetova G, Lee B, Bonifacino E, Wu Y, Proia R . S1P1 receptor directs the release of immature B cells from bone marrow into blood. J Exp Med. 2010; 207(5):1113-24. PMC: 2867276. DOI: 10.1084/jem.20092210. View