Isolation and Identification of Two New Compounds from the Twigs and Leaves of Cephalotaxus Fortunei

Overview

Journal J Nat Med

Publisher Springer

Date 2019 Apr 13

PMID 30976949

Authors

Qingmei Feng

Bingxin Li

Yuan Feng

Xingyu Li

Xiaorui Ma

Haifeng Wang

Gang Chen

Affiliations

Soon will be listed here.

Abstract

Two new compounds, namely 5-hydroxy-7-methoxy-6-methylchromone (1), and sesquiterpene X (6), together with 21 known compounds were isolated from the twigs and leaves of Cephalotaxus fortunei Hook. f. The structures of 1-23 were elucidated on the basis of spectroscopic analysis (1D/2D NMR, HR-ESI-MS and IR) and comparison with literature. The absolute configuration of compound 6 was determined by means of electronic circular dichroism calculation. The in vitro anti-inflammatory activities of all compounds were assayed in RAW 264.7 cells by assessing lipopolysaccharide-induced nitric oxide production. Compounds 1 and 6 exhibited weak effects with percentage inhibitions of 24% and 35.60%, respectively. In addition, compounds 4, 9, and 14 have the potential to be developed as therapeutic agents for inflammatory diseases because of their significant anti-inflammatory activities and high content in C. fortunei.

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