Evidence of Tumour Microenvironment and Stromal Cellular Components in Retinoblastoma

Overview

Journal Ocul Oncol Pathol

Date 2019 Apr 13

PMID 30976585

Citations 11

Authors

Rajeswari Raguraman

Sowmya Parameswaran

Jagat Rakesh Kanwar

Vikas Khetan

Pukhraj Rishi

Rupinder Kaur Kanwar

Subramanian Krishnakumar

Affiliations

Soon will be listed here.

Abstract

Background: The tumour microenvironment (TME) consisting of tumour cells and multiple stromal cell types regulate tumour growth, invasion and metastasis. While the concept of TME and presence of stromal cellular components is widely established in cancers, its significance in the paediatric intraocular malignancy, retinoblastoma (RB), remains unknown.

Methods: The study qualitatively identified the presence of multiple stromal cellular subtypes in RB TME by immunohistochemistry.

Results: Results of the study identified the presence of stromal cell types such as endothelial cells, tumour-associated macrophages, fibroblasts, cancer-associated fibroblasts, retinal astrocytes and glia in RB TME. The extent of stromal marker positivity, however, did not correlate with histopathological features of RB.

Conclusions: The findings of the study convincingly suggest the presence of a stromal component in RB tumours. The interactions between stromal cells and tumour cells might be of profound importance in RB progression.

Citing Articles

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Characterization and Optimization of the Tumor Microenvironment in Patient-Derived Organotypic Slices and Organoid Models of Glioblastoma.

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Growth Inhibition of Retinoblastoma Cell Line by Exosome-Mediated Transfer of miR-142-3p.

Plousiou M, De Vita A, Miserocchi G, Bandini E, Vannini I, Melloni M Cancer Manag Res. 2022; 14:2119-2131.

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Single-cell characterization of malignant phenotypes and microenvironment alteration in retinoblastoma.

Wu C, Yang J, Xiao W, Jiang Z, Chen S, Guo D Cell Death Dis. 2022; 13(5):438.

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