Two Component Regulatory Systems and Antibiotic Resistance in Gram-Negative Pathogens

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Apr 13

PMID 30974906

Citations 66

Authors

Anjali Y Bhagirath

Yanqi Li

Rakesh Patidar

Katherine Yerex

Xiaoxue Ma

Ayush Kumar

Kangmin Duan

Affiliations

Soon will be listed here.

Abstract

Gram-negative pathogens such as , , and are the leading cause of nosocomial infections throughout the world. One commonality shared among these pathogens is their ubiquitous presence, robust host-colonization and most importantly, resistance to antibiotics. A significant number of two-component systems (TCSs) exist in these pathogens, which are involved in regulation of gene expression in response to environmental signals such as antibiotic exposure. While the development of antimicrobial resistance is a complex phenomenon, it has been shown that TCSs are involved in sensing antibiotics and regulating genes associated with antibiotic resistance. In this review, we aim to interpret current knowledge about the signaling mechanisms of TCSs in these three pathogenic bacteria. We further attempt to answer questions about the role of TCSs in antimicrobial resistance. We will also briefly discuss how specific two-component systems present in , , and may serve as potential therapeutic targets.

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